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5,​7,​4'-​Trimethoxyflavone

Catalog No. T8296   CAS 5631-70-9
Synonyms: Apoptosis, poly ADP ribose polymerase, 5,​7,​4' ​Trimethoxyflavone, Caspase, inhibit, 4',5,7-Trimethoxyflavone, 5,​7,​4'​Trimethoxyflavone, 5,?7,?4'-?Trimethoxyflavone, Inhibitor, PARP, Endogenous Metabolite

5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
5,​7,​4'-​Trimethoxyflavone, CAS 5631-70-9
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Purity: 98%
Biological Description
Chemical Properties
Storage & Solubility Information
Description 5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.
In vitro 5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of PARP protein. 5,7,4'-Trimethoxyflavone is significantly effective at inhibiting the proliferation of SNU-16 human gastric cancer cells in a concentration-dependent manner.
Synonyms Apoptosis, poly ADP ribose polymerase, 5,​7,​4' ​Trimethoxyflavone, Caspase, inhibit, 4',5,7-Trimethoxyflavone, 5,​7,​4'​Trimethoxyflavone, 5,?7,?4'-?Trimethoxyflavone, Inhibitor, PARP, Endogenous Metabolite
Molecular Weight 312.321
Formula C18H16O5
CAS No. 5631-70-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Kim H, et al. Induction of ER Stress-Mediated Apoptosis by the Major Component 5,7,4'-TrimethoxyflavoneIsolated from Kaempferia parviflora Tea Infusion. Nutr Cancer. 2018 Aug-Sep;70(6):984-996.

Related compound libraries

This product is contained In the following compound libraries：
Anti-Cancer Compound Library Flavonoid Natural Product Library Anti-Cardiovascular Disease Compound Library Traditional Chinese Medicine Monomer Library Natural Product Library for HTS Anti-Tumor Natural Product Library DNA Damage & Repair Compound Library Anti-Breast Cancer Compound Library Apoptosis Compound Library Epigenetics Compound Library

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