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5-Geranoxy-7-methoxycoumarin

Catalog No. TN3110   CAS 7380-39-4

5-Geranoxy-7-methoxycoumarin shows antifungal activity.

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5-Geranoxy-7-methoxycoumarin Chemical Structure
5-Geranoxy-7-methoxycoumarin, CAS 7380-39-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 106.00
5 mg In stock $ 257.00
10 mg In stock $ 380.00
25 mg In stock $ 638.00
50 mg In stock $ 890.00
100 mg In stock $ 1,230.00
1 mL * 10 mM (in DMSO) In stock $ 270.00
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Purity: 99.99%
Purity: 99.99%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 5-Geranoxy-7-methoxycoumarin shows antifungal activity.
In vitro Two mechanisms of the resistance of citrus fruits against pathogens-preformed and induced antifungal materials-were investigated. METHODS AND RESULTS: Flavedo tissue of lemon contains the following preformed antifungal materials: citral, limettin, 5-Geranoxy-7-methoxycoumarin, and isopimpinellin, which act as the first line of defense against pathogens. Exogenous application of citral to Penicillium-inoculated lemon fruit prevented development of decay. Being subjected to fungal challenge and/or abiotic stress, citrus fruits are elicited to produce the phytoalexin scoparone, considered as another line of fruit defense. According to median effective dose (ED50) of the inhibition of germ-tube elongation or percent germination, scoparone had higher fungitoxicity against Penicillium digitatum Sacc. than the preformed antifungal materials. Different citrus species (lemon, orange, grapefruit, lime, kumquat) varied in their capacities to produce scoparone responding to the combined Penicillium inoculation and heat treatment or to UV illumination. UV illumination of lemon fruit reduced its susceptibility to P. digitatum. CONCLUSIONS: Expression of this effect was directly related to the level of scoparone in illuminated fruit. UV light and citral application were visibly injurious to the flavedo tissues in high dose.
Source
Molecular Weight 328.4
Formula C20H24O4
CAS No. 7380-39-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.28 mg/mL (10 mM)

TargetMolReferences and Literature

1. Preformed and induced antifungal materials of citrus fruits in relation to the enhancement of decay resistance by heat and ultraviolet treatments. Journal of Agricultural and Food Chemistry, 1992, 40(7):1217-1221.

TargetMolCitations

1. Li S, Kelly C, Knob R, et al.Analysis of Coumarin-Based Phototoxins in Citrus-Derived Essential Oils Using Liquid Chromatography-Mass Spectrometry.Chromatographia.2023: 1-11.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Cancer Compound Library RO5 Drug-like Natural Product Library Anti-infective Natural Product Library Human Metabolite Library Natural Product Library NO PAINS Compound Library Bioactive Compounds Library Max Anti-Fungal Compound Library Anti-Bacterial Compound Library

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Keywords

5-Geranoxy-7-methoxycoumarin 7380-39-4 Microbiology/Virology Anti-infection Antibacterial Antifungal Apoptosis 5 Geranoxy 7 methoxycoumarin Bacterial Fungal antifungal inhibit DNA fragmentation 5Geranoxy7methoxycoumarin Inhibitor inhibitor

 

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