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5-Hydroxy-1-methylhydantoin

Catalog No. T28222   CAS 84210-26-4
Synonyms: HD-003, HD003, NZ419, NZ-419, HD 003, NZ 419

5-Hydroxy-1-methylhydantoin (HD-003) is an antioxidant potentially for the treatment of renal failure. A creatinine metabolite, 5-Hydroxy-1-methylhydantoin , a hydroxyl radical scavenger, has previously been shown to confer renoprotection by inhibiting the progression of chronic kidney disease in rats. 5-Hydroxy-1-methylhydantoin is a novel anti-oxidant drug completely suppressed the expression of B2-kinin receptors (B2KR) in response to high glucose (25 mM) stimulation in VSMC and was also shown to attenuate the effects of BK on VSMC remodeling. 5-Hydroxy-1-methylhydantoin inhibited the BK-induced increase in MAPK phosphorylation and attenuated the increase in connective tissue growth factor (CTGF) protein levels in VSMC. These findings suggest that 5-Hydroxy-1-methylhydantoin may confer vascular protection against high glucose concentrations and BK-stimulation to ameliorate vascular injury and remodeling through its anti-oxidant properties.

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5-Hydroxy-1-methylhydantoin Chemical Structure
5-Hydroxy-1-methylhydantoin, CAS 84210-26-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 148.00
5 mg In stock $ 336.00
10 mg In stock $ 493.00
25 mg In stock $ 790.00
50 mg In stock $ 1,120.00
100 mg In stock $ 1,490.00
500 mg In stock $ 2,970.00
1 mL * 10 mM (in DMSO) In stock $ 233.00
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Purity: 99.50%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 5-Hydroxy-1-methylhydantoin (HD-003) is an antioxidant potentially for the treatment of renal failure. A creatinine metabolite, 5-Hydroxy-1-methylhydantoin , a hydroxyl radical scavenger, has previously been shown to confer renoprotection by inhibiting the progression of chronic kidney disease in rats. 5-Hydroxy-1-methylhydantoin is a novel anti-oxidant drug completely suppressed the expression of B2-kinin receptors (B2KR) in response to high glucose (25 mM) stimulation in VSMC and was also shown to attenuate the effects of BK on VSMC remodeling. 5-Hydroxy-1-methylhydantoin inhibited the BK-induced increase in MAPK phosphorylation and attenuated the increase in connective tissue growth factor (CTGF) protein levels in VSMC. These findings suggest that 5-Hydroxy-1-methylhydantoin may confer vascular protection against high glucose concentrations and BK-stimulation to ameliorate vascular injury and remodeling through its anti-oxidant properties.
Synonyms HD-003, HD003, NZ419, NZ-419, HD 003, NZ 419
Molecular Weight 130.1
Formula C4H6N2O3
CAS No. 84210-26-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (525.85 mM)

TargetMolReferences and Literature

1. Ienaga K, Sohn M, Naiki M, Jaffa AA. Creatinine metabolite, HMH (5-hydroxy-1-methylhydantoin; NZ-419), modulates bradykinin-induced changes in vascular smooth muscle cells. J Recept Signal Transduct Res. 2014 Jun;34(3):195-200. 2. Ienaga K, Park CH, Yokozawa T. Protective effect of an intrinsic antioxidant, HMH (5-hydroxy-1-methylhydantoin; NZ-419), against cellular damage of kidney tubules. Exp Toxicol Pathol. 2013 Jul;65(5):559-66. doi: 10.1016/j.etp.2012.05.001. PubMed PMID: 22749566. 3. Ienaga K, Yokozawa T. Creatinine and HMH (5-hydroxy-1-methylhydantoin, NZ-419) as intrinsic hydroxyl radical scavengers. Drug Discov Ther. 2011 Aug;5(4):162-75. PubMed PMID: 22466296. 4. Hasegawa G, Nakano K, Ienaga K. Serum accumulation of a creatinine oxidative metabolite (NZ-419: 5-hydroxy-1- methylhydatoin) as an intrinsic antioxidant in diabetic patients with or without chronic kidney disease. Clin Nephrol. 2011 Oct;76(4):284-9. PubMed PMID: 21955863.

Related compound libraries

This product is contained In the following compound libraries:
GPCR Compound Library Human Metabolite Library Inhibitor Library Antioxidant Compound Library NO PAINS Compound Library ReFRAME Related Library Bioactive Compound Library Bioactive Compounds Library Max Oxidation-Reduction Compound Library

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Keywords

5-Hydroxy-1-methylhydantoin 84210-26-4 GPCR/G Protein Bradykinin Receptor 5Hydroxy1methylhydantoin HD-003 HD003 NZ419 NZ-419 HD 003 NZ 419 5 Hydroxy 1 methylhydantoin inhibitor inhibit

 

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