Powder: -20°C for 3 years | In solvent: -80°C for 1 year
5J-4 is a potent a blocker of calcium release-activated calcium (CRAC) channel and store-operated calcium entry (SOCE). 5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 98.00 | |
10 mg | In stock | $ 154.00 | |
25 mg | In stock | $ 263.00 | |
50 mg | In stock | $ 395.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 111.00 |
Description | 5J-4 is a potent a blocker of calcium release-activated calcium (CRAC) channel and store-operated calcium entry (SOCE). 5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt. |
In vivo | 5J-4 (2 mg/kg; i.p.; every alternate day for 30 days) dramatically reduced the symptoms and delayed the onset of EAE and decreased the numbers of the infiltrated mononuclear cell in the CNS, and significantly decreased the population of infiltrated CD4+ population. 5J-4 reduced the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in the mouse model of inflammation[1]. |
Molecular Weight | 312.34 |
Formula | C16H12N2O3S |
CAS No. | 827001-82-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (160.08 mM)
You can also refer to dose conversion for different animals. More
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5J-4 827001-82-1 Membrane transporter/Ion channel Metabolism Calcium Channel Inhibitor Calcium release-activated channels CRAC Channel CNS Ca2+ release-activated Ca2+ channels 5J 4 inflammation 5J4 inhibit CD4+ cells mononuclear cell experimental autoimmune encephalomyelitis inhibitor