Powder: -20°C for 3 years | In solvent: -80°C for 1 year
6-Hydroxybenzbromarone is the major metabolite of Benzbromarone. 6-Hydroxybenzbromarone is a protein Eyes Absent 3 (EYA3) inhibitor (IC50: 21.5 μM). It is an angiogenic agent, has strong inhibitory effects on cell migration, tubulogenesis, and angiogenic sprouting.
Pack Size | Availability | Price/USD | Quantity |
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2 mg | 5 days | $ 416.00 |
Description | 6-Hydroxybenzbromarone is the major metabolite of Benzbromarone. 6-Hydroxybenzbromarone is a protein Eyes Absent 3 (EYA3) inhibitor (IC50: 21.5 μM). It is an angiogenic agent, has strong inhibitory effects on cell migration, tubulogenesis, and angiogenic sprouting. |
Targets&IC50 | EYA3:21.5 μM |
In vitro | 6-Hydroxybenzbromarone (7.5 μM; 72 hours) shows an over 50% reduction in cell proliferation. Meanwhile, treatment with BBR and BZ also reduces cell viability, but none of the other compounds tested has a negative impact on cell viability or proliferation. 6-Hydroxybenzbromarone (7.5 μM; 1-20 hours) has inhibitory effects EC migration tubulogenesis of HUVECs. However, the effect of 6OH-BBR on tube formation is attenuated in the presence of high concentrations of fetal bovine serum (FBS), likely reflecting non-specific protein binding. |
Cell Research | Cell Line: HUVEC cells. Concentration: 7.5 μM. Incubation Time: 72 hours |
Molecular Weight | 440.08 |
Formula | C17H12Br2O4 |
CAS No. | 152831-00-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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6-Hydroxybenzbromarone 152831-00-0 Others 6 Hydroxybenzbromarone 6Hydroxybenzbromarone inhibitor inhibit