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7,8-Dihydroxyflavone

Catalog No. T2816 CAS 38183-03-8

Synonyms: 7,8-DHF

7,8-Dihydroxyflavone (7,8-DHF) is a naturally-occurring flavone and exist in Tridax procumbens, Godmania aesculifolia, and primula tree leaves.

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7,8-Dihydroxyflavone, CAS 38183-03-8

Pack Size	Availability	Price/USD
10 mg	In stock	$ 30.00
50 mg	In stock	$ 68.00
100 mg	In stock	$ 90.00
1 mL * 10 mM (in DMSO)	In stock	$ 54.00

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Purity: 99.47%

Purity: 98.37%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	7,8-Dihydroxyflavone (7,8-DHF) is a naturally-occurring flavone and exist in Tridax procumbens, Godmania aesculifolia, and primula tree leaves.
Targets&IC50	TrkB receptor:320 nM(Kd)
In vitro	7,8-DHF is one of the positive compounds that specifically activate TrkB, but not TrkA or TrkC, at a concentration of 250 nM. In addition to cortical and hippocampal neurons, 7,8-DHF also protects other cell types including the RGC (retinal ganglion cells) and PC12 cells from excitotoxic and oxidative stress-induced apoptosis and cell death. Thus, it has neuroprotective properties[1].
In vivo	7,8-Dihydroxyflavone is a bioavailable chemical that can pass through the BBB to provoke TrkB and its downstream PI3K/Akt and MAPK activation in mouse brain upon intraperitoneal or oral administration. 7,8-DHF promotes the survival and reduces apoptosis in cortical neurons of traumatic brain injury as administration of 7,8-DHF at 3 h post-injury reduces brain tissue damage via the PI3K/Akt pathway. Its treatment does not induce any apparent toxicity in mice and is not toxic to the mice during the chronic treatment. 7,8-DHF displays robust therapeutic efficacy toward Alzheimer's disease and inhibits obesity through activating muscular TrkB[1].
Cell Research	PC12 cells are seeded in 96-well plates at 104/well. After pretreatment with 7,8-DHF (1-25 μM) for 1 h, the cells are exposed to 6-OHDA (100 μM) for subsequent 24 h. The PI3k inhibitor LY294002 or MEK inhibitor PD98059 is added 30 min before 7,8-DHF treatment. At the end of the experiment, PC12 cells are incubated with 20 μl of MTT solution (5 mg/ml in PBS) for 4 h at 37 ?C. The dark blue formazan product due to the reduction of MTT is dissolved in 150 μl of DMSO, and the absorbance at 570 nm is recorded with a microplate reader. The viability is expressed as the percentage of the untreated control cells. (Only for Reference)
Source	Natural Products > Fabaceae > Pueraria

Synonyms	7,8-DHF
Molecular Weight	254.24
Formula	C15H10O4
CAS No.	38183-03-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 47 mg/mL (184.9 mM)

Ethanol: 1 mg/mL (3.93 mM)

References and Literature

1. Liu C, et al. Transl Neurodegener. 2016, 5:2. 2. Bollen E, et al. Behav Brain Res. 2013, 257:8-12. 3. Han XH, et al. Neurosci Lett. 2014, 581:85-8.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Anti-Neurodegenerative Disease Compound Library Kinase Inhibitor Library Natural Product Library for HTS Anti-Tumor Natural Product Library Target-Focused Phenotypic Screening Library Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library Human Metabolite Library Bioactive Compounds Library Max Ferroptosis Compound Library

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Keywords

7,8-Dihydroxyflavone 38183-03-8 Apoptosis Tyrosine Kinase/Adaptors Trk receptor Trk Receptor Inhibitor Tropomyosin related kinase receptor 7,8-DHF inhibit 7,8Dihydroxyflavone 7,8 Dihydroxyflavone inhibitor

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