Powder: -20°C for 3 years | In solvent: -80°C for 1 year
7-Chlorokynurenic acid sodium salt (7-CKA sodium salt) is a potent and selective antagonist of the glycine B coagonist site of the NMDA receptor (IC50: 0.56 μM). It is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles (Ki: 0.59 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 44.00 | |
1 mL * 10 mM (in DMSO) | 5 days | $ 64.00 |
Description | 7-Chlorokynurenic acid sodium salt (7-CKA sodium salt) is a potent and selective antagonist of the glycine B coagonist site of the NMDA receptor (IC50: 0.56 μM). It is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles (Ki: 0.59 μM). |
Targets&IC50 | Reuptake of glutamate:(ki)0.59 μM , Glycine B coagonist site of NMDA receptor:0.56 μM |
In vivo | Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid sodium salt (10 nM) shows significant retardation of the development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response [3]. |
Synonyms | 7-CKA sodium salt |
Molecular Weight | 246.6 |
Formula | C10H6ClNNaO3 |
CAS No. | 1263094-00-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 50 mg/mL (203.59 mM), sonification is recommended.
DMSO: 33.67 mg/mL (137.10 mM)
You can also refer to dose conversion for different animals. More
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7-Chlorokynurenic acid sodium salt 1263094-00-3 Others 7-CKA sodium 7-CKA sodium salt 7Chlorokynurenic acid sodium salt 7-Chlorokynurenic acid sodium 7 Chlorokynurenic acid sodium salt inhibitor inhibit