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8-M-PDOT
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Catalog No. T10198Cas No. 134865-70-6
Alias AH-002, 8-Methoxy-2-propionamidotetralin
8-M-PDOT (AH-002) is a selective and potent melatonin MT2 receptor agonist that also inhibits MT1 receptors. 8-M-PDOT exhibits anxiolytic activity and can be used to study MT2-induced neuropathic pain.
8-M-PDOT
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Purity: 99.54%
Catalog No. T10198Alias AH-002, 8-Methoxy-2-propionamidotetralinCas No. 134865-70-6
8-M-PDOT (AH-002) is a selective and potent melatonin MT2 receptor agonist that also inhibits MT1 receptors. 8-M-PDOT exhibits anxiolytic activity and can be used to study MT2-induced neuropathic pain.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $30 | 5 days | |
| 5 mg | $64 | In Stock | |
| 10 mg | $118 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $71 | 5 days |
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Purity:99.54%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | 8-M-PDOT (AH-002) is a selective and potent melatonin MT2 receptor agonist that also inhibits MT1 receptors. 8-M-PDOT exhibits anxiolytic activity and can be used to study MT2-induced neuropathic pain. |
| Targets&IC50 | MT2 receptor:8.23 (pKi), MT1 receptor:8.95 (pKi) |
| In vivo | Treatment with 8-M-PDOT (10 µg/µL; administered into the dorsal striatum by bilateral cannulas; for 30 minutes; male Wistar rats) demonstrates an anxiolytic-like effect[2]. |
| Animal Research | Animal Model: Male Wistar rats (280-320 g) with Rotenone [2]. Dosage: 10 μg/μL. Administration: Administrated into the dorsal striatum by bilateral cannulas; for 30 minutes |
| Alias | AH-002, 8-Methoxy-2-propionamidotetralin |
| Molecular Weight | 233.31 |
| Formula | C14H19NO2 |
| Cas No. | 134865-70-6 |
| Smiles | CCC(=O)NC1CCc2cccc(OC)c2C1 |
| Relative Density. | 1.09g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (214.31 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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