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9-Hydroxyellipticine hydrochloride

Catalog No. T10200 CAS 52238-35-4

9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and RyR. It exhibits antitumor, antioxidant and catecholamine-releasing activities. 9-Hydroxyellipticine hydrochloride inihibits Hela S-3 and 293T cells (IC50s: 1.6 μM and 1.2μM).

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9-Hydroxyellipticine hydrochloride Chemical Structure

9-Hydroxyellipticine hydrochloride, CAS 52238-35-4

Pack Size	Availability	Price/USD
1 mg	4-5 weeks	$ 78.00
5 mg	4-5 weeks	$ 363.00
10 mg	4-5 weeks	$ 653.00
25 mg	4-5 weeks	$ 1,420.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and RyR. It exhibits antitumor, antioxidant and catecholamine-releasing activities. 9-Hydroxyellipticine hydrochloride inihibits Hela S-3 and 293T cells (IC50s: 1.6 μM and 1.2μM).
In vitro	9-Hydroxyellipticine selectively inhibits p53 protein phosphorylation in both Lewis lung carcinoma and SW480 (human colon cancer cell line), demonstrating a concentration-dependent effect ranging from 0.1 to 100 μM [4].
In vivo	9-Hydroxyellipticine (5 or 10 mg/kg, ip) results in chromosome clumping and sister chromatid exchange in murine bone marrow cells [1].

Molecular Weight	298.77
Formula	C17H15ClN2O
CAS No.	52238-35-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Renault G, et al. In vivo exposure to four ellipticine derivatives with topoisomerase inhibitory activity results in chromosome clumping and sister chromatid exchange in murine bone marrow cells. Toxicol Appl Pharmacol. 1987 Jun 30;89(2):281-6. 2. Saeki K, et al. Cardioprotective effects of 9-hydroxyellipticine on ischemia and reperfusion in isolated rat heart. Jpn J Pharmacol. 2002 May;89(1):21-8. 3. Naoya Sato, et al. Synthesis and in vitro Antitumor Activity of 9-Hydroxyellipticine Derivatives with Glucose Conjugation via Triazolylmethyl Succinate Linker. Heterocycle, Vol. 92, NO 4, 2016. 4. Ohashi M, et al. Inhibition of p53 protein phosphorylation by 9-hydroxyellipticine: a possible anticancer mechanism. Jpn J Cancer Res. 1995 Sep;86(9):819-27.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

9-Hydroxyellipticine hydrochloride 52238-35-4 Others 9Hydroxyellipticine hydrochloride 9-Hydroxyellipticine Hydrochloride 9 Hydroxyellipticine hydrochloride inhibitor inhibit

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