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A 779 TFA(159432-28-7 free base)

Catalog No. T7616L   CAS T7616L
Synonyms: A 779 3TFA(159432-28-7(free base))

A 779 TFA is a potent antagonist of angiotensin-(1-7) receptor.

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A 779 TFA(159432-28-7 free base) Chemical Structure
A 779 TFA(159432-28-7 free base), CAS T7616L
Pack Size Availability Price/USD Quantity
1 mg In stock $ 50.00
5 mg In stock $ 62.00
10 mg In stock $ 92.00
25 mg In stock $ 167.00
50 mg In stock $ 250.00
100 mg In stock $ 375.00
1 mL * 10 mM (in DMSO) In stock $ 139.00
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Purity: 100%
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Biological Description
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Description A 779 TFA is a potent antagonist of angiotensin-(1-7) receptor.
In vitro A-779 suppresses the proliferating cell nuclear antigen (PCNA) protein expression up-regulated by Ang II, but A-779 alone has no effect to induce proliferation and migration of VSMCs.?Pretreatment with Ang-(1-7) significantly retards Ang II-induced inflammatory responses of VSMCs associated with up-regulated MCP-1, VCAM-1 and IL-1β expressions, and this effect of Ang-(1-7) is blocked by A-779.?But A-779 alone has no effect to induce inflammatory response of VSMCs[1].
In vivo Inhibition of Ang1-7 cascade by A-779 significantly eradicated captopril protective effects on bone metabolism, mineralization and micro-structure.?A-779 also restored OVX effects on RANKL expression and ACE-1/AngII/AT1R cascade and down-regulated OPG expression and ACE-2/Ang1-7/Mas pathway.?In line with the clinical observations of the bone-preservative properties following ACE-1 inhibition, local activation of ACE-2/Ang1-7/Mas signaling and suppressed osteoclastogenesis seem responsible for the osteo-preservative effect of captopril, which could offers a potential therapeutic value in treatment of disabling bone and skeletal muscular diseases[2].
Cell Research HUVECs were cultured in vitro and divided into six groups:?the control group (normal medium), the ox-LDL group(treated with 75 mg/L ox-LDL), the ox-LDL+ Ang-(1-7) group (1 μmol/L Ang-(1-7) pretreated for 30 minutes, then intervened with 75 mg/L ox-LDL), the ox-LDL+ Ang-(1-7)+ A-779 group(1 μmol/L A-779 (Mas receptor) pretreated for 30 minutes, 1 μmol/L Ang-(1-7) pretreated for 30 minutes, then intervened with 75 mg/L ox-LDL), the ox-LDL+ A-779 group (1 μmol/L A-779 pretreated for 30 minutes, then intervened with 75 mg/L ox-LDL),?the ox-LDL+ HTA125 group (10 μg/L HTA125 (TLR4-blocking antibody) pretreated for 30 minutes, then intervened with 75 mg/L ox-LDL ).?The corresponding index was detected after 24 hours after intervention.?Apoptosis of cells were detected by Annexin V-FITC/PI double staining flow cytometry and transferase-mediated deoxyuridine triphosphate-biotin nick end labeling (TUNEL).?The generation of reactive oxygen species (ROS), products in oxidative stress, were detected by DCFH-DA staining.?The mRNA and protein expression levels of NADPH oxidase 4(NOX4) and TLR4 were detected by real-time reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting analysis respectively[1].
Synonyms A 779 3TFA(159432-28-7(free base))
Molecular Weight 987.01
Formula C41H61F3N12O13
CAS No. T7616L

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 9.87 mg/mL (10 mM)

TargetMolReferences and Literature

1. Yan W F , Xue J J , Yang H Y , et al. [Effects and related mechanism of angiotensin-(1-7) on Toll-like receptor 4-mediated oxidative stress in human umbilical vein endothelial cells].[J]. Zhonghua Xin Xue Guan Bing Za Zhi, 2017, 45(3):223. 2. Abuohashish H M , Ahmed M M , Sabry D , et al. ACE-2/Ang1-7/Mas cascade mediates ACE inhibitor, captopril, protective effects in estrogen-deficient osteoporotic rats[J]. Biomedicine & Pharmacotherapy, 2017, 92:58-68.

Related compound libraries

This product is contained In the following compound libraries:
Endocrinology-Hormone Compound Library Bioactive Compound Library Angiogenesis related Compound Library NO PAINS Compound Library Anti-Hypertension Compound Library Inhibitor Library Bioactive Compounds Library Max

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Keywords

A 779 TFA(159432-28-7 free base) T7616L Endocrinology/Hormones RAAS A 779 3TFA(159432-28-7(free base)) A 779 TFA(159432 28 7 free base) A 779 TFA(159432287 free base) inhibitor inhibit

 

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