Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Aβ42-IN-1 free base (compound 1v), an orally active γ-secretase modulator with high brain exposure, effectively lowers Aβ42 levels, exhibiting an IC 50 of 0.091 μM, and significantly diminishes brain Aβ42 levels in mice. Given these properties, Aβ42-IN-1 free base represents a potential disease-modifying agent for Alzheimer’s disease [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | Aβ42-IN-1 free base (compound 1v), an orally active γ-secretase modulator with high brain exposure, effectively lowers Aβ42 levels, exhibiting an IC 50 of 0.091 μM, and significantly diminishes brain Aβ42 levels in mice. Given these properties, Aβ42-IN-1 free base represents a potential disease-modifying agent for Alzheimer’s disease [1]. |
In vivo | Aβ42-IN-1 free base treatment exhibits that the CL int value is 84.7 μL/min/mg protein [1]. Animal Model: Nonfasted 8-week-old male ddY mice [1] Dosage: 30 mg/kg Administration: p.o. (Pharmacokinetic Analysis) Result: The CL int is 84.7 μL/min/mg protein. |
Molecular Weight | 462.54 |
Formula | C29H26N4O2 |
CAS No. | 2434633-17-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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