Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AB-680 is a highly potent, reversible, and selective inhibitor of CD73 (an ectonucleotidase, Ki: 4.9 pM for hCD73) with anti-tumor activity, displays <10,000-fold selectivity over related ectonucleotidases CD39.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 115.00 | |
2 mg | In stock | $ 163.00 | |
5 mg | In stock | $ 247.00 | |
10 mg | In stock | $ 393.00 | |
25 mg | In stock | $ 658.00 | |
50 mg | In stock | $ 937.00 | |
100 mg | In stock | $ 1,270.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 316.00 |
Description | AB-680 is a highly potent, reversible, and selective inhibitor of CD73 (an ectonucleotidase, Ki: 4.9 pM for hCD73) with anti-tumor activity, displays >10,000-fold selectivity over related ectonucleotidases CD39. |
Targets&IC50 | CD73:4.9 pM (ki;human), CD73:43 pM (Soluble hCD73) |
In vitro | AB-680 inhibits soluble hCD73 (IC50: 0.043 nM), also inhibits hCD73 in CHO cells, suppresses CD73 in human, mouse CD8+ T Cells and hPBMC, with IC50s of 0.070, 0.008, 0.66 and 0.011 nM, respectively. |
Molecular Weight | 580.82 |
Formula | C20H24ClFN4O9P2 |
CAS No. | 2105904-82-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 180 mg/mL (309.91 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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AB-680 2105904-82-1 Immunology/Inflammation CD73 Inhibitor AB680 inhibit AB 680 inhibitor