Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ABBV-4083 is a Tylosin A analog that has potent anti-Wolbachia and anti-filarial activity.
Pack Size | Availability | Price/USD | Quantity |
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25 mg | Inquiry | $ 1,520.00 |
Description | ABBV-4083 is a Tylosin A analog that has potent anti-Wolbachia and anti-filarial activity. |
In vivo | ABBV-4083 (150 mg/kg, once daily for 14 days) reduces Wolbachia levels (measured 16 weeks post-treatment-initiation, pti) in mice by >99.9% in the recovered female adult worms. Levels of circulating microfilariae declines from ~7 weeks pti and are completely cleared from 12 weeks pti until the end of this study at 16 weeks pti. |
Animal Research | Animal Model: Female BALB/c mice or female jirds were infected at 6–8 weeks of age with L. sigmodontis larvae through the bites of Ornithonyssus bacoti mites. Dosage: 150 mg/kg. Administration: PO once daily for 14 days started at 14 weeks post-infection (pti). |
Molecular Weight | 1024.21 |
Formula | C53H82FNO17 |
CAS No. | 1809266-03-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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ABBV-4083 1809266-03-2 Others ABBV 4083 ABBV4083 inhibitor inhibit