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ABC1183

Catalog No. T23601 CAS 1042735-18-1

Synonyms: ABC 1183, ABC-1183

ABC1183 is a novel diaminothiazole that inhibits GSK3α, GSK3β and CDK9. ABC1183 inhibits the growth of a numerous cancer cell lines by decreasing cell survival by inducing G2/M arrest and through altering GSK3, glycogen synthetase, β-catenin phosphorylation and MCL1 expression,and is orally active.

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ABC1183, CAS 1042735-18-1

Pack Size	Availability	Price/USD
5 mg	In stock	$ 59.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 198.00
50 mg	In stock	Inquiry
1 mL * 10 mM (in DMSO)	In stock	$ 66.00

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Purity: 98.53%

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Storage & Solubility Information

Description	ABC1183 is a novel diaminothiazole that inhibits GSK3α, GSK3β and CDK9. ABC1183 inhibits the growth of a numerous cancer cell lines by decreasing cell survival by inducing G2/M arrest and through altering GSK3, glycogen synthetase, β-catenin phosphorylation and MCL1 expression,and is orally active.
Targets&IC50	GSK-3β:657 nM, GSK-3α:327 nM, CDK9-CyclinT1:321 nM
In vitro	ABC1183 inhibits cell proliferation and tumor growth of various cancer types by specifically attenuating GSK3 and CDK9 activity. ABC1183 altered GSK3 activity as indicated by decreased GSK3α/β and GS phosphorylation and increased β-catenin phosphorylation[1].
In vivo	Murine melanoma B16 tumors were propagated in C57BL/6 mice were treated with oral ABC1183 or vehicle. Tumor growth was decreased more than 70% within 8 days by ABC1183 treatment. On the basis of body weight, gross toxicities were not observed. ABC1183 was determined to suppress tumor growth in the absence of organ and hematopoietic toxicity. The expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) were suppressed[1][2].

Synonyms	ABC 1183, ABC-1183
Molecular Weight	334.39
Formula	C18H14N4OS
CAS No.	1042735-18-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.34 mg/mL (10 mM), Sonication is recommended.

References and Literature

1. Schrecengost RS, et al. In Vitro and In Vivo Antitumor and Anti-Inflammatory Capabilities of the Novel GSK3 and CDK9 Inhibitor ABC1183. J Pharmacol Exp Ther. 2018 Apr;365(1):107-116. 2. Duda P, et al. Targeting GSK3 and Associated Signaling Pathways Involved in Cancer. Cells. 2020 Apr 30;9(5):1110.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max Kinase Inhibitor Library Metabolism Compound Library Anti-Obesity Compound Library Anti-Cancer Compound Library

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Keywords

ABC1183 1042735-18-1 Cell Cycle/Checkpoint PI3K/Akt/mTOR signaling Stem Cells GSK-3 CDK ABC 1183 ABC-1183 inhibitor inhibit

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