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AC 187 Acetate

Catalog No. T21581L CAS T21581L

Synonyms: AC 187 Acetate (151804-77-2 Free base)

AC 187 Acetate is a potent antagonist of Amylin Receptor .AC 187 shows more selective for Amylin Receptor than calcitonin and CGRP receptors.

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AC 187 Acetate, CAS T21581L

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AC 187 Acetate is a potent antagonist of amylin receptor .AC 187 shows more selective for amylin receptor than calcitonin and CGRP receptors.
Targets&IC50	amylin receptor:0.48 nM
In vitro	AC187 attenuates the activation of initiator and effector caspases that mediate Aβ-induced apoptotic cell death.

Synonyms	AC 187 Acetate (151804-77-2 Free base)
Molecular Weight	2950.26
Formula	C129H209N37O42
CAS No.	T21581L

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: 90 mg/mL (29.96 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Jack H Jhamandas, et al. Antagonist of the amylin receptor blocks beta-amyloid toxicity in rat cholinergic basal forebrain neurons. J Neurosci. 2004 Jun 16;24(24):5579-84.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AC 187 Acetate T21581L GPCR/G Protein Amylin Receptor AC 187 Acetate (151804-77-2 Free base) Inhibitor inhibitor inhibit

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