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AD 0261

Catalog No. T10253   CAS 145600-69-7

AD 0261 is a radical scavenger. It has a strong inhibitory action on the generation of lipid peroxides and superoxide anions.

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AD 0261 Chemical Structure
AD 0261, CAS 145600-69-7
Pack Size Availability Price/USD Quantity
25 mg 8-10 weeks $ 1,520.00
50 mg 8-10 weeks $ 1,980.00
100 mg 8-10 weeks $ 2,500.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description AD 0261 is a radical scavenger. It has a strong inhibitory action on the generation of lipid peroxides and superoxide anions.
In vitro AD 0261 displays strong inhibitory action on the generation of lipid peroxides (IC50: 0.022 μM) and superoxide anions (IC50: 0.9-4.0 μM). It inhibits cytokine release and/or production from PHA-P-stimulated lymphocytes in a dose-dependent manner. AD 0261 inhibits all parameters which are indicative of lymphocyte activation with 50% inhibition being achieved in a range of 1-10 μM. AD 0261 suppresses ornithine decarboxylase activity (IC50: ~1.0 μM).
Cell Research For measurement of [3H]TdR incorporation, cells are incubated for 16 h, and additional (6 h) incubation is carried out in the presence of [3H]TdR (0.5 μCi/well). [3H]TdR incorporation is evaluated in a liquid scintillation counter. IL-2 release from lymphocytes is estimated after 20 h incubation by enzyme immunoassay using the commercially available kits. IL-2 receptor expression is quantitated by flow cytometry using a FITC-labelled monoclonal antibody which recognizes a chain of the IL-2 receptor complex. Cell viability is determined by either the trypan blue exclusion test or propidium iodide staining.
Molecular Weight 451.55
Formula C27H31F2N3O
CAS No. 145600-69-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. M. Sugiura, et al. Effect of the novel radical scavenger AD0261 on lymphocyte activation. Information Research. Agents and Actions. August 1994, Volume 41, Supplement 2, pp C216-C218.

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Keywords

AD 0261 145600-69-7 Others AD0261 AD-0261 inhibitor inhibit

 

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