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AGN 194078

Catalog No. T10265 CAS 321995-62-4

AGN 194078 is a selective RARα agonist (Kd: 3 nM; EC50: 112 nM).

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AGN 194078, CAS 321995-62-4

Pack Size	Availability	Price/USD
25 mg	8-10 weeks	$ 1,520.00
50 mg	8-10 weeks	$ 1,980.00
100 mg	8-10 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AGN 194078 is a selective RARα agonist (Kd: 3 nM; EC50: 112 nM).
Targets&IC50	RARα:112 nM （EC50）, RARα:3 nM （Kd)
In vitro	AGN 194078 binds to RARα with very high affinity (Kd: 3 nM), while being unable to bind to RARβ and binding only very weakly (Kd=5600 nM) to RARγ. Furthermore, AGN 194078 maintains full transcriptional activity through RARα, with an EC50 value of 112 nM, but only activated RARβ and RARγ with about 10% efficacy at the highest dose (1000 nM) tested.

Molecular Weight	403.42
Formula	C22H23F2NO4
CAS No.	321995-62-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Beard RL, et al. Synthesis and biological activity of retinoic acid receptor-alpha specific amides. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3145-8.

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Keywords

AGN 194078 321995-62-4 Others AGN-194078 AGN194078 inhibitor inhibit

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