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AGN 196996

Catalog No. T10261 CAS 958295-17-5

AGN 196996 is a potent and selective inhibitor of RARα (Ki: 2 nM).AGN 196996 has very low affinity for RARβ and RARγ, with a Ki of 1087 nM and 8523 nM, respectively.

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AGN 196996, CAS 958295-17-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 97.00
5 mg	In stock	$ 263.00
10 mg	In stock	$ 395.00
25 mg	In stock	$ 659.00
50 mg	In stock	$ 939.00
100 mg	In stock	$ 1,280.00
1 mL * 10 mM (in DMSO)	In stock	$ 278.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	AGN 196996 is a potent and selective inhibitor of RARα (Ki: 2 nM).AGN 196996 has very low affinity for RARβ and RARγ, with a Ki of 1087 nM and 8523 nM, respectively.
Targets&IC50	RARβ:1087 nM(Ki), RARα:2 nM(Ki), RARγ:8523 nM(Ki)
In vitro	AGN 196996 is a potent and selective RARα antagonist with a Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM). RARα antagonist AGN 196996 shows no activity in transactivation assays but instead blocks the gene transcriptional activity induced by ATRA and other RAR agonists.[1]

Molecular Weight	482.32
Formula	C24H20BrNO5
CAS No.	958295-17-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 225.0 mg/mL (466.5 mM), Sonification is recommended.

References and Literature

1. Hammond LA, et al. Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells. Br J Cancer. 2001 Aug 3;85(3):453-62. 2. Keedwell RG, et al. An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium. Br J Cancer. 2004 Aug 2;91(3):580-8.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library Autophagy Compound Library

Related Products

Related compounds with same targets

Etodolac BMS 195614 K-8012 Ch55 CD3254 TTNPB Liarozole Magnolol

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AGN 196996 958295-17-5 Autophagy Metabolism Others Retinoid Receptor AGN196996 AGN-196996 inhibitor inhibit

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