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ALK inhibitor 1

Catalog No. T10285 CAS 761436-81-1

Synonyms: serine/threonine, Anaplastic lymphoma kinase (ALK), CD246, PTK2 protein tyrosine kinase 2, ALK inhibitor 1, IGF-1R, Cluster of differentiation 246, kinase, focal, ALK inhibitor1, Inhibitor, ALK inhibitor-1, male, adhesion, reversible, TSSK2, Focal adhesion kinase, ALK tyrosine kinase receptor, contraception, inhibit, Anaplastic lymphoma kinase, PTK2, testis-specific, FAK

ALK inhibitor 1 is a selective ALK kinase inhibitor.

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ALK inhibitor 1, CAS 761436-81-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	ALK inhibitor 1 is a selective ALK kinase inhibitor.
Targets&IC50	IGF-1R: 90 nM
In vitro	ALK inhibitor 1 inhibits IGF-1R.

Synonyms	serine/threonine, Anaplastic lymphoma kinase (ALK), CD246, PTK2 protein tyrosine kinase 2, ALK inhibitor 1, IGF-1R, Cluster of differentiation 246, kinase, focal, ALK inhibitor1, Inhibitor, ALK inhibitor-1, male, adhesion, reversible, TSSK2, Focal adhesion kinase, ALK tyrosine kinase receptor, contraception, inhibit, Anaplastic lymphoma kinase, PTK2, testis-specific, FAK
Molecular Weight	562.48
Formula	C23H28BrN7O3S
CAS No.	761436-81-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: 0.1 mg/mL (insoluble)

DMSO: 90 mg/mL (160.01mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. A Dose Finding Study With Oral LDK378 in Patients With Tumors Characterized by Genetic Abnormalities in Anaplastic Lymphoma Kinase (ALK).

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.