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Aloin(mixture of A&B)

Catalog No. T5680   CAS 8015-61-0

ALOIN Inhibits Interleukin (IL)-1β-Stimulated IL-8 Production in KB Cells.

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Aloin(mixture of A&B) Chemical Structure
Aloin(mixture of A&B), CAS 8015-61-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 39.00
5 mg In stock $ 88.00
10 mg In stock $ 122.00
25 mg In stock $ 198.00
50 mg In stock $ 297.00
100 mg In stock $ 453.00
500 mg In stock $ 987.00
1 mL * 10 mM (in DMSO) In stock $ 97.00
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description ALOIN Inhibits Interleukin (IL)-1β-Stimulated IL-8 Production in KB Cells.
In vitro Clostridium histolyticum collagenase (ChC) results dose-dependently inhibited by aloe gel and the activity-guided fractionation led to an active fraction enriched in phenolics and aloins.?Aloins have been shown to be able to bind and to inhibit ChC reversibly and non-competitively.?Aloe gel and aloins are also effective inhibitors of stimulated granulocyte matrix metalloproteinases (MMPs)[1].
In vivo Aloin effectively inhibits salivary IL-1β-induced IL-8 production by mitigating the p38 and ERK pathway. Therefore, aloin may be a good candidate for modulating oral inflammatory diseases[2].
Animal Research Saliva was collected from volunteers to determine IL-1β and IL-8 levels. Samples from volunteers were divided into two groups: those with low and those with high IL-1β levels. KB cells were stimulated with IL-1β or saliva with or without IL-1 receptor agonist or specific mitogen-activated protein kinase (MAPK) inhibitors. IL-8 production was measured by enzyme-linked immunosorbent assay (ELISA). MAPK protein expression involved in IL-1β-induced IL-8 secretion was detected by Western blot. KB cells were pretreated with?aloin, and its effect on IL-1β-induced IL-8 production was examined by ELISA and Western blot analysis[1].
Source
Molecular Weight N/A
CAS No. 8015-61-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (119.51 mM)

TargetMolReferences and Literature

1. Barrantes E , Guinea M . Inhibition of collagenase and metalloproteinases by aloins and aloe gel[J]. Life Sciences, 2003, 72(7):0-850. 2. Na H S , Song Y R , Kim S , et al. Aloin Inhibits Interleukin (IL)‐1β−Stimulated IL‐8 Production in KB Cells[J]. Journal of Periodontology, 2016, 87(6):1-15.

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Keywords

Aloin(mixture of A&B) 8015-61-0 Immunology/Inflammation Microbiology/Virology Proteases/Proteasome Antibacterial MMP IL Receptor Antifungal inhibit Matrix metalloproteinases Bacterial Inhibitor Fungal inhibitor

 

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