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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TQ0127 | Navtemadlin | AMG232 , CS-1300 | Mdm2 , E1/E2/E3 Enzyme |
Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM. |