Powder: -20°C for 3 years | In solvent: -80°C for 1 year
APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 36.00 | |
5 mg | In stock | $ 59.00 | |
10 mg | In stock | $ 97.00 | |
25 mg | In stock | $ 186.00 | |
50 mg | In stock | $ 317.00 | |
100 mg | In stock | $ 572.00 | |
500 mg | In stock | $ 1,190.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 65.00 |
Description | APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity. |
Targets&IC50 | IRE1α:280 nM |
In vitro | APY29 selectively influences IRE1α by divergently modulating its RNase activity and oligomerization state through the same binding site, showing opposing effects on RNase activity. Additionally, APY29 has a dose-dependent, contrasting impact on ER stress-induced activation of the endogenous IRE1α RNase [1]. |
Molecular Weight | 332.36 |
Formula | C17H16N8 |
CAS No. | 1216665-49-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 33.24 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
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APY29 1216665-49-4 Cell Cycle/Checkpoint IRE1 APY-29 inhibit Inhibitor Inositol requiring enzyme 1 APY 29 inhibitor