Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AR453588 is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 1,650.00 | |
50 mg | 8-10 weeks | $ 2,150.00 | |
100 mg | 8-10 weeks | $ 3,400.00 |
Description | AR453588 is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity. |
In vivo | AR453588 (3-30 mg/kg; p.o) lowers post-prandial glucose in normal C57BL/6J mice. AR453588 (3-30 mg/kg; p.o.; once-daily for 14 days) shows anti-hyperglycemic activity in a dose-ranging 14-day ob/ob mouse. AR453588 (10 mg/kg; p.o.) treatment shows that the Tmax, AUCinf, Vss, Cmax and F are 1.0 mL/min/kg, 4.65 h μg /mL, 1.67 μg /mL and 60.3%, respectively. AR453588 (1 mg/kg; i.v.) treatment shows that the CL, AUCinf, Vss, and t1/2 are 21.6 mL/min/kg, 0.77 h μg /mL, 0.746 L/kg and 1.28 hours, respectively. |
Molecular Weight | 519.64 |
Formula | C25H25N7O2S2 |
CAS No. | 1065609-00-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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AR453588 1065609-00-8 Others AR 453588 AR-453588 inhibitor inhibit