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AS1269574

Catalog No. T21623   CAS 330981-72-1
Synonyms: AS 1269574

AS1269574 is a potent, orally available GPR119 agonist. AS1269574(AS 1269574) has the potential for the research of type 2 diabetes.

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AS1269574 Chemical Structure
AS1269574, CAS 330981-72-1
Pack Size Availability Price/USD Quantity
2 mg In stock $ 41.00
5 mg In stock $ 64.00
10 mg In stock $ 109.00
25 mg In stock $ 207.00
50 mg In stock $ 328.00
100 mg In stock $ 490.00
500 mg In stock $ 1,090.00
1 mL * 10 mM (in DMSO) In stock $ 80.00
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Purity: 99.98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description AS1269574 is a potent, orally available GPR119 agonist. AS1269574(AS 1269574) has the potential for the research of type 2 diabetes.
In vitro AS1269574 had an EC(50) value of 2.5μM in HEK293 cells transiently expressing human GPR119 and enhanced insulin secretion in the mouse pancreatic β-cell line MIN-6 only under high-glucose (16.8mM) conditions.?This contrasted with the action of the sulfonylurea glibenclamide, which also induced insulin secretion under low-glucose conditions (2.8mM)[1].
In vivo In in vivo studies, a single administration of AS1269574 to normal mice reduced blood glucose levels after oral glucose loading based on the observed insulin secretion profiles.?Significantly, AS1269574 did not affect fed and fasting plasma glucose levels in normal mice.?AS1269574 represents a novel structural class of small molecule, orally administrable GPR119 agonists with GSIS and promising potential for the treatment of type 2 diabetes[1].
Synonyms AS 1269574
Molecular Weight 308.17
Formula C13H14BrN3O
CAS No. 330981-72-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (811.24 mM), sonification is recommended.

TargetMolReferences and Literature

1. Yoshida S, et al. Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo glucose-stimulated insulin secretion. Biochem Biophys Res Commun. 2010;400(3):437-441. 2. Chepurny OG, et al. GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion. Mol Endocrinol. 2016;30(6):614-629.

Related compound libraries

This product is contained In the following compound libraries:
Neuronal Signaling Compound Library Anti-Diabetic Compound Library Ion Channel Inhibitor Library NO PAINS Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Endocrinology-Hormone Compound Library GPCR Compound Library Orally Active Compound Library Bioactive Compound Library

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Keywords

AS1269574 330981-72-1 Endocrinology/Hormones GPCR/G Protein Membrane transporter/Ion channel GPR TRP/TRPV Channel TRP Channel G Protein-Coupled Receptor 119 secretion AS 1269574 Inhibitor type cation AS-1269574 diabetes insulin inhibit Transient receptor potential channels glucose GPR119 channels inhibitor

 

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