Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ASM-024, a potent nicotinic receptor agonist, is a small molecule synthetic piperazine compound that promotes different targets and signaling pathways of β2-adrenergic receptors mediating smooth muscle relaxation, and is a potential compound for the treatment of asthma and chronic obstructive bronchitis with anti-inflammatory activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 258.00 | |
5 mg | In stock | $ 642.00 | |
10 mg | In stock | $ 913.00 | |
25 mg | In stock | $ 1,370.00 | |
50 mg | In stock | $ 1,850.00 | |
100 mg | In stock | $ 2,500.00 | |
500 mg | In stock | $ 4,900.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 533.00 |
Description | ASM-024, a potent nicotinic receptor agonist, is a small molecule synthetic piperazine compound that promotes different targets and signaling pathways of β2-adrenergic receptors mediating smooth muscle relaxation, and is a potential compound for the treatment of asthma and chronic obstructive bronchitis with anti-inflammatory activity. |
In vitro | Incubation of HBSMC cells with ASM-024 did not induce significant production of cAMP compared to salbutamol or formoterol treated cells.[1] Fifteen minutes of incubation of hBSMC with ASM-024 alone had no effect on [Ca2+]i. However, a 10 minute pre-treatment with ASM-024 decreased [Ca2+]i rise in cells challenged with 10-6 M histamine or methacholine.[1] |
In vivo | ASM-024 increased in vitro relaxation response to maximally effective concentration of short—acting beta-2 agonists in dog and human bronchi.[1] ASM-024 induces smooth muscle relaxation of β2-AR desensitized tracheas.[1] |
Molecular Weight | 233.37 |
Formula | C15H25N2 |
CAS No. | 1609534-88-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2.34 mg/mL (10.01 mM)
You can also refer to dose conversion for different animals. More
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ASM-024 1609534-88-4 Neuroscience AChR ASM 024 ASM-024 cation ASM024 inhibitor inhibit