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ASP1126

Catalog No. T10387   CAS 1228580-11-7

ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist (EC50s: 7.12 nM, 517 nM for hS1P1 and hS1P3).

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ASP1126 Chemical Structure
ASP1126, CAS 1228580-11-7
Pack Size Availability Price/USD Quantity
25 mg 6-8 weeks $ 1,670.00
50 mg 6-8 weeks $ 2,180.00
100 mg 6-8 weeks $ 2,800.00
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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
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Biological Description
Chemical Properties
Storage & Solubility Information
Description ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist (EC50s: 7.12 nM, 517 nM for hS1P1 and hS1P3).
Targets&IC50 S1P1 (human):(EC50)7.12 nM , S1P3 (human): 517 nM
In vitro ASP1126 decreases the number of peripheral lymphocytes, naive T cells, central memory T cells, and effector memory T cells in the peripheral blood.
In vivo ASP1126 (1 and 5 mg/kg, orally once daily for 14 days) significantly prolongs allograft survival. ASP1126 in combination with 0.02 mg/kg tacrolimus notably improves graft survival time.
Molecular Weight 581.93
Formula C26H26ClF6NO5
CAS No. 1228580-11-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Okimoto A, et al. ASP1126, a Novel Sphingosine-1-Phosphate-Selective Agonist With a Favorable Safety Profile, Prolongs Allograft Survival in Rats and Nonhuman Primates in Combination With Tacrolimus With a Broad Safety Margin for Bradycardia. Transplant Proc. 2019 Jul - Aug;51(6):2081-2098.

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Keywords

ASP1126 1228580-11-7 Others ASP 1126 ASP-1126 inhibitor inhibit

 

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