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ATWLPPR Peptide TFA

Catalog No. T10408 CAS T10408

ATWLPPR Peptide TFA is a selective neuropilin-1 inhibitor and inhibits VEGF165 binding to NRP-1. It has the potential in reducing the early retinal damage caused by diabetes.

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ATWLPPR Peptide TFA, CAS T10408

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Biological Description

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Description	ATWLPPR Peptide TFA is a selective neuropilin-1 inhibitor and inhibits VEGF165 binding to NRP-1. It has the potential in reducing the early retinal damage caused by diabetes.
In vitro	ATWLPPR Peptide TFA inhibits VEGF165 binding to NRP-1 by 82% at 100 μM [1].
In vivo	ATWLPPR (400 μg/kg, s.c.) maintains vascular integrity and reduces oxidative stress, potentially mitigating early diabetic-related retinal damage. It inhibits the elevation of inflammation-associated proteins (GFAP, VEGF, and ICAM-1) in the retina [2].

Molecular Weight	954
Formula	C42H62F3N11O11
CAS No.	T10408

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 50 mg/mL (52.41 mM)

References and Literature

1. Starzec A, et al. Structure-function analysis of the antiangiogenic ATWLPPR peptide inhibiting VEGF(165) binding to neuropilin-1 and molecular dynamics simulations of the ATWLPPR/neuropilin-1 complex. Peptides. 2007 Dec;28(12):2397-402. 2. Wang J, et al. The Neuropilin-1 Inhibitor, ATWLPPR Peptide, Prevents Experimental Diabetes-Induced Retinal Injury by Preserving Vascular Integrity and Decreasing Oxidative Stress. PLoS One. 2015 Nov 10;10(11):e0142571.

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Keywords

ATWLPPR Peptide TFA T10408 Others inhibitor inhibit

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