Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 51.00 | |
2 mg | In stock | $ 74.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 197.00 | |
25 mg | In stock | $ 347.00 | |
50 mg | In stock | $ 542.00 | |
100 mg | In stock | $ 782.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 133.00 |
Description | AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell. |
Targets&IC50 | ATM:0.31 μM (in cell), ATM:6.2 nM |
In vitro | AZ32 is an enhanced blood-brain barrier (BBB)-penetrating ATM inhibitor. AZ32 blocks the DNA damage response and radiosensitized GBM cells in vitro[1]. |
In vivo | AZ32 has enhanced BBB penetration that is highly efficient in vivo as radiosensitizer in syngeneic and human, orthotopic mouse glioma model compared with AZ31. AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse. Following a single oral dose of AZ32 (200 mg/kg) in mice, the free-brain concentrations of AZ32 are in excess of the cellular IC50 for approximately 22 hours[1]. |
Molecular Weight | 328.37 |
Formula | C20H16N4O |
CAS No. | 2288709-96-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 150 mg/mL
You can also refer to dose conversion for different animals. More
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AZ32 2288709-96-4 DNA Damage/DNA Repair PI3K/Akt/mTOR signaling ATM/ATR Ataxia telangiectasia mutated ATM and RAD3 related inhibit Inhibitor AZ 32 AZ-32 inhibitor