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AZ32

Catalog No. T4443   CAS 2288709-96-4

AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.

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AZ32 Chemical Structure
AZ32, CAS 2288709-96-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 51.00
2 mg In stock $ 74.00
5 mg In stock $ 122.00
10 mg In stock $ 197.00
25 mg In stock $ 347.00
50 mg In stock $ 542.00
100 mg In stock $ 782.00
1 mL * 10 mM (in DMSO) In stock $ 133.00
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Purity: 99.94%
Purity: 99.68%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.
Targets&IC50 ATM:0.31 μM (in cell), ATM:6.2 nM
In vitro AZ32 is an enhanced blood-brain barrier (BBB)-penetrating ATM inhibitor. AZ32 blocks the DNA damage response and radiosensitized GBM cells in vitro[1].
In vivo AZ32 has enhanced BBB penetration that is highly efficient in vivo as radiosensitizer in syngeneic and human, orthotopic mouse glioma model compared with AZ31. AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse. Following a single oral dose of AZ32 (200 mg/kg) in mice, the free-brain concentrations of AZ32 are in excess of the cellular IC50 for approximately 22 hours[1].
Molecular Weight 328.37
Formula C20H16N4O
CAS No. 2288709-96-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 150 mg/mL

TargetMolReferences and Literature

1. Karlin J, et al. Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice. Mol Cancer Ther. 2018 Aug;17(8):1637-1647. 2. Liu K, Li Y C, Chen Y, et al. AZ32 reverses ABCG2-mediated multidrug resistance in colorectal cancer[J]. Frontiers in Oncology. 2021, 11: 1764.

TargetMolCitations

1. Liu K, Li Y C, Chen Y, et al. AZ32 reverses ABCG2-mediated multidrug resistance in colorectal cancer. Frontiers in Oncology. 2021, 11: 1764.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Bioactive Compounds Library Max Orally Active Compound Library Anti-Pancreatic Cancer Compound Library Neural Regeneration Compound Library Anti-Prostate Cancer Compound Library Preclinical Compound Library Kinase Inhibitor Library Oxidation-Reduction Compound Library Anti-Colorectal Cancer Compound Library

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ATM Inhibitor-8 Elimusertib hydrochloride(1876467-74-1 free base) ATM Inhibitor-1 azd1390 Tuvusertib M3541 AZ20 Dactolisib

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Keywords

AZ32 2288709-96-4 DNA Damage/DNA Repair PI3K/Akt/mTOR signaling ATM/ATR Ataxia telangiectasia mutated ATM and RAD3 related inhibit Inhibitor AZ 32 AZ-32 inhibitor

 

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