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AZA197

Catalog No. T25125 CAS 1249398-09-1

Synonyms: AZA 197, AZA-197

AZA197 (AZA-197) is a selective Cdc42 inhibitor. It acts by inhibiting primary colon cancer growth and prolonging survival in a preclinical mouse xenograft model by downregulation of PAK1 activity.

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AZA197, CAS 1249398-09-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 329.00
5 mg	In stock	$ 798.00
10 mg	In stock	$ 1,090.00
25 mg	In stock	$ 1,650.00
50 mg	In stock	$ 2,230.00
100 mg	In stock	$ 2,930.00

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Purity: 100%

Biological Description

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Description	AZA197 (AZA-197) is a selective Cdc42 inhibitor. It acts by inhibiting primary colon cancer growth and prolonging survival in a preclinical mouse xenograft model by downregulation of PAK1 activity.
In vitro	In SW620 and HT-29 human colon cancer cells, AZA197(1, 2, 5 and 10 μM; 24 h) demonstrated selectivity for Cdc42 without inhibition of Rac1 or RhoA GTPases from the same family. AZA197 suppressed colon cancer cell proliferation, cell migration and invasion and increased apoptosis associated with down-regulation of the PAK1 and ERK signaling pathways in vitro[1].
In vivo	Systemic AZA197(i.p. injections with 100 μg) treatment reduced tumor growth in vivo and significantly increased mouse survival in SW620 tumor xenografts. Ki-67 staining and tissue TUNEL assays showed that both inhibition of cell proliferation and induction of apoptosis associated with reduced PAK/ERK activation contributed to the AZA197-induced therapeutic effects in vivo[1].

Synonyms	AZA 197, AZA-197
Molecular Weight	408.58
Formula	C24H36N6
CAS No.	1249398-09-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Slightly soluble

References and Literature

1. Zins K, et al. Targeting Cdc42 with the small molecule drug AZA197 suppresses primary colon cancer growth and prolongs survival in a preclinical mouse xenograft model by downregulation of PAK1 activity. J Transl Med. 2013 Nov 27;11:295. 2. Goodman RB, et al. Identification of two neutrophil chemotactic peptides produced by porcine alveolar macrophages. J Biol Chem. 1991 May 5;266(13):8455-63. PubMed PMID: 1850745.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library Kinase Inhibitor Library Bioactive Compound Library

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Keywords

AZA197 1249398-09-1 Cell Cycle/Checkpoint CDK AZA 197 AZA-197 inhibitor inhibit

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