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Cell Cycle/Checkpoint Aurora Kinase AZD1152

AZD1152

Catalog No. T14371   CAS 722543-31-9
Synonyms: Barasertib
Purity 98.00% Datasheet

AZD1152 is a pro-drug of Barasertib-hQPA, which is a highly selective inhibitor of Aurora B (IC50:0.37 nM, in a cell-free assay).

AZD1152, CAS 722543-31-9
Pack Size Availability Price/USD Quantity
5 mg inquiry 124.00
10 mg inquiry 204.00
50 mg inquiry 803.00
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1 mL * 10 mM (in DMSO) inquiry 159.00
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Purity 98.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description AZD1152 is a pro-drug of Barasertib-hQPA, which is a highly selective inhibitor of Aurora B (IC50:0.37 nM, in a cell-free assay).
Targets&IC50 Aurora B :ic50 0.37 nM,  
In vivo Administration of AZD1152 (25 mg/kg) alone markedly suppresses the growth of MOLM13 xenografts, confirmed by the observation of necrotic tissue with infiltration of phagocytic cells[1]. AZD1152 (25 mg/kg/day) treatment reduces xenograft levels such that they are slightly lower levels than after the first round of treatment, but this is not statistically significant indicating that residual cells might be more resistant to a second cycle of AZD1152[4]. In addition, AZD1152 (10-150 mg/kg/day) significantly inhibits the growth of a variety of human solid tumor xenografts, including colon, breast, and lung cancers, in a dose-dependent manner[2].
Synonyms Barasertib
Purity 98.00%
Molecular Weight 587.54
Formula C26H31FN7O6P
CAS No. 722543-31-9

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 33 mg/mL (56.17 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Yang J, et al. AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo. Blood. 2007 Sep 2. Wilkinson RW, et al. AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis. Clin Cancer Res. 2007 Jun 15;13(12):3682-8. 3. Evans RP, et al. The selective Aurora B kinase inhibitor AZD1152 is a potential new treatment for multiple myeloma. Br J Haematol. 2008 Feb;140(3):295-302. 4. Oke A, et al. AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells in vitro and in vivo. Cancer Res. 2009 May 15;69(10):4150-8.

Related Products

Related compounds with same targets
SP-146 Aurora Kinase Inhibitor III SNS-314 Mesylate Aurora inhibitor 1 SCH-1473759 AZD1152 MBM-17S MBM-17

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