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AZD9056 hydrochloride

Catalog No. T14385 CAS 345303-91-5

AZD9056 hydrochloride is a P2X7 inhibitor，Which plays a significant role in pain-causing diseases and inflammation.

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AZD9056 hydrochloride Chemical Structure

AZD9056 hydrochloride, CAS 345303-91-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 39.00
2 mg	In stock	$ 56.00
5 mg	In stock	$ 93.00
10 mg	In stock	$ 158.00
25 mg	In stock	$ 352.00
50 mg	In stock	$ 587.00
100 mg	In stock	$ 839.00
1 mL * 10 mM (in DMSO)	In stock	$ 98.00

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Purity: 99.52%

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Description	AZD9056 hydrochloride is a P2X7 inhibitor，Which plays a significant role in pain-causing diseases and inflammation.
Targets&IC50	P2X7:11.2 nM
In vitro	The antagonist AZD9056 blocks P2X7 receptors with an IC50 of 11.2 nM in HEK-hP2X7 cell line, indicating a high selectivity of the antagonist for the P2X7 receptor.The P2X7-receptor antagonist AZD9056 has a clear inhibitory effect (IC50=1-3 μM) in mouse microglia BV2 cells[1].
In vivo	Treatment with AZD9056 demonstrates analgesic and anti-inflammatory properties by reversing the MIA-induced upregulation of interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), matrix metalloproteinase-13 (MMP-13), substance P (SP), and prostaglandin E2 (PGE2) in cartilage tissues.

Molecular Weight	455.46
Formula	C24H36Cl2N2O2
CAS No.	345303-91-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 48 mg/mL (105.39 mM), Sonification is recommended.

References and Literature

1. Seeland S, et al. ATP-induced cellular stress and mitochondrial toxicity in cells expressing purinergic P2X7 receptor. Pharmacol Res Perspect. 2015 Mar;3(2):e00123. 2. Elsby R, et al. In vitro risk assessment of AZD9056 perpetrating a transporter-mediated drug-drug interaction with methotrexate. Eur J Pharm Sci. 2011 May 18;43(1-2):41-9. 3. Hu H, et al. Blocking of the P2X7 receptor inhibits the activation of the MMP-13 and NF-κB pathways in the cartilage tissue of rats with osteoarthritis. Int J Mol Med. 2016 Dec;38(6):1922-1932.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Inhibitor Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Neuronal Signaling Compound Library Ion Channel Inhibitor Library Immunology/Inflammation Compound Library Bioactive Compounds Library Max Orally Active Compound Library Clinical Compound Library

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Keywords

AZD9056 hydrochloride 345303-91-5 Membrane transporter/Ion channel Neuroscience P2X Receptor AZD 9056 Hydrochloride AZD 9056 AZD-9056 AZD9056 Hydrochloride P2XRs Inhibitor AZD-9056 Hydrochloride AZD-9056 hydrochloride AZD9056 inhibit inhibitor

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