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Acebilustat

Catalog No. T3715   CAS 943764-99-6
Synonyms: CTX-4430

Acebilustat (CTX-4430) (ZK322) is an effective and specific leukotriene B4 hydrolase inhibitor.

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Acebilustat Chemical Structure
Acebilustat, CAS 943764-99-6
Pack Size Availability Price/USD Quantity
1 mg In stock $ 38.00
2 mg In stock $ 54.00
5 mg In stock $ 89.00
10 mg In stock $ 122.00
25 mg In stock $ 247.00
50 mg In stock $ 393.00
100 mg In stock $ 585.00
1 mL * 10 mM (in DMSO) In stock $ 98.00
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Purity: 99.59%
Purity: 99.47%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Acebilustat (CTX-4430) (ZK322) is an effective and specific leukotriene B4 hydrolase inhibitor.
In vitro Acebilustat is a leukotriene A4 hydrolase inhibitor, which is safe and well tolerated in phase 1 trial[1]. Acebilustat is an antiinflammatory drug in development for the treatment of CF and other diseases. It is a potent inhibitor of the enzyme leukotriene A4 hydrolase (LTA4H), which catalyzes the rate-limiting step in the formation of leukotriene B4 (LTB4), a potent chemoattractant and activator of inflammatory immune cells including neutrophils[2].
Kinase Assay Rolapitant is made at a stock concentration of 1 mM in 100% DMSO. For most receptor binding studies, the stock solution is diluted with the final concentrations ranged from 0.1 to 3 μM. Radioligand concentrations for competition binding studies ranged from 0.5 to 1 nM. For species comparison studies, 150 pM [125I]-BHSP is incubated with varying concentrations of protein (10-50 μg) prepared from gerbil, rabbit and monkey striata, and from cells expressing cloned rat, mouse and guinea pig NK receptors[1].
Synonyms CTX-4430
Molecular Weight 481.54
Formula C29H27N3O4
CAS No. 943764-99-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mM

Methanol: 32 mg/mL

TargetMolReferences and Literature

1. Elborn JS, et al. Phase 1 Studies of Acebilustat: Biomarker Response and Safety in Patients with Cystic Fibrosis. Clin Transl Sci. 2016 Nov 2. 2. Elborn JS, et al. Phase I Studies of Acebilustat: Pharmacokinetics, Pharmacodynamics, Food Effect, and CYP3A Induction. Clin Transl Sci. 2016 Oct 28.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Fibrosis Compound Library Coagulation and Anticoagulation Compound Library Nonsteroidal Anti-Inflammatory Compound Library Bioactive Compound Library Bioactive Compounds Library Max Metabolism Compound Library Clinical Compound Library Orally Active Compound Library Inhibitor Library Immunology/Inflammation Compound Library

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Keywords

Acebilustat 943764-99-6 Immunology/Inflammation Metabolism LTR Aminopeptidase CTX 4430 Inhibitor inhibit CTX4430 CTX-4430 inhibitor

 

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