Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Acolbifene (SCH 57068) is a selective antagonist of estrogen receptors with IC50s of 2 nM and 0.4 nM for estradiol-induced transcriptional activity of ERα and ERβ. Acolbifene shows an anticarcinogenic property.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 76.00 | |
5 mg | In stock | Inquiry | |
50 mg | 6-8 weeks | Inquiry | |
1 mL * 10 mM (in DMSO) | In stock | $ 199.00 |
Description | Acolbifene (SCH 57068) is a selective antagonist of estrogen receptors with IC50s of 2 nM and 0.4 nM for estradiol-induced transcriptional activity of ERα and ERβ. Acolbifene shows an anticarcinogenic property. |
Targets&IC50 | ERβ:0.4 nM (IC50, E2-induced transcriptional activity), ERα:2 nM (IC50, E2-induced transcriptional activity) |
In vitro | Acolbifene supports the involvement of the clearance-related receptors in its hypocholesterolemic action without affecting pathways of cholesterol synthesis[2]. Acolbifene inhibits estradiol-stimulated cell proliferation in human breast cancer cancer cells including ZR-75-1, MCF-7 and T-47D[4]. |
In vivo | In female Sprague-Dawley rats, Acolbifene (2.5 mg/kg; gavage) reduces food intake, strongly decreases cholesterolemia and prevents tumor growth. Acolbifene reduces food intake (16%) and weight gain (45%, mainly fat)[2]. |
Synonyms | EM-652, SCH 57068 |
Molecular Weight | 457.56 |
Formula | C29H31NO4 |
CAS No. | 182167-02-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40 mg/mL (87.4 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Acolbifene 182167-02-8 Endocrinology/Hormones Estrogen Receptor/ERR EM-652 SCH 57068 SCH-57068 EM 652 SCH57068 EM652 inhibitor inhibit