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Acrivastine

Catalog No. T4551   CAS 87848-99-5
Synonyms: Acrivastin, BW825C, Semprex

Acrivastine (Acrivastin) is a short-acting histamine 1 receptor antagonist.

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Acrivastine Chemical Structure
Acrivastine, CAS 87848-99-5
Pack Size Availability Price/USD Quantity
5 mg In stock $ 31.00
10 mg In stock $ 47.00
25 mg In stock $ 100.00
50 mg In stock $ 163.00
100 mg In stock $ 233.00
500 mg In stock $ 583.00
1 g In stock $ 833.00
1 mL * 10 mM (in DMSO) In stock $ 34.00
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Purity: 100%
Purity: 99.85%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Acrivastine (Acrivastin) is a short-acting histamine 1 receptor antagonist.
In vivo Acrivastine (usually 8mg three times daily) is an effective and well-tolerated antihistamine in the treatment of chronic urticaria and allergic rhinitis. Acrivastine causes less drowsiness than clemastine, the incidence of adverse effects being indistinguishable from that with placebo or terfenadine. In the treatment of dermatoses in which histamine has a pathogenetic role, the efficacy of acrivastine is superior to that of placebo and similar to that of usual dosages of clemastine, hydroxyzine, chlorpheniramine, cyproheptadine or terfenadine [1]. Both 4 mg and 8 mg acrivastine alleviate the symptoms of seasonal allergic rhinitis with significant improvements in the symptom scores for sneezing, running nose and the calculated overall score. In addition, 8 mg acrivastine reduces the symptom scores for watery eyes and itchy throat. Acrivastine is both well tolerated and effective in the treatment of seasonal allergic rhinitis [2].
Synonyms Acrivastin, BW825C, Semprex
Molecular Weight 348.44
Formula C22H24N2O2
CAS No. 87848-99-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mg/mL (14.35 mM), Sonification is recommended

TargetMolReferences and Literature

1. Brogden RN, et al. Acrivastine. A review of its pharmacological properties and therapeutic efficacy in allergic rhinitis, urticaria and related disorders. Drugs. 1991 Jun;41(6):927-40. 2. Gibbs TG, et al. Acrivastine in two doses compared with placebo in a multicentre, parallel group study for the treatment of seasonal allergic rhinitis. Br J Clin Pract. 1989 Jan;43(1):11-4.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Anti-Cancer Compound Library Bioactive Compounds Library Max FDA-Approved Drug Library Human Metabolite Library Nonsteroidal Anti-Inflammatory Compound Library Drug-induced Liver Injury (DILI) Compound Library NO PAINS Compound Library Anti-COVID-19 Compound Library

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Keywords

Acrivastine 87848-99-5 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor Acrivastin inhibit BW825C Semprex Inhibitor inhibitor

 

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