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Adaphostin

Catalog No. T22553 CAS 241127-58-2

Synonyms: 1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate, NSC 680410

Adaphostin (NSC-680410) is a p210Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 μM.

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Adaphostin, CAS 241127-58-2

Pack Size	Availability	Price/USD
5 mg	In stock	$ 64.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 198.00
50 mg	In stock	$ 328.00
100 mg	In stock	$ 493.00
500 mg	In stock	$ 1,070.00

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Purity: 97.31%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Adaphostin (NSC-680410) is a p210Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 μM.
Targets&IC50	p210 (BCR-ABL):14 μM
In vitro	It also induces apoptosis in T-lymphoblastic human leukemia cell lines (IC50 values range from 16.8 to 216.3 nM) in vitro.
In vivo	Adaphostin can damage both myeloid and lymphoid leukemia cells[2].

Synonyms	1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate, NSC 680410
Molecular Weight	393.48
Formula	C24H27NO4
CAS No.	241127-58-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 40 mg/mL (101.66 mM)

DMSO: < 40 mg/mL (101.66 mM)

References and Literature

1. Svingen PA, et al. Effects of the bcr/abl kinase inhibitors AG957 and NSC 680410 on chronic myelogenous leukemia cells in vitro. Clin Cancer Res. 2000;6(1):237-249. 2. Chandra J, et al. Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells. Blood. 2003;102(13):4512-4519. 3. Orsolic N, et al. Adaphostin has significant and selective activity against chronic and acute myeloid leukemia cells. Cancer Sci. 2006;97(9):952-960.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Inhibitor Library Cytoskeletal Signaling Pathway Compound Library Angiogenesis related Compound Library Bioactive Compounds Library Max Anti-Cancer Metabolism Compound Library Bioactive Compound Library Kinase Inhibitor Library ReFRAME Related Library Anti-Cancer Compound Library

Related Products

Related compounds with same targets

Olverembatinib Imatinib impurities3 Vamotinib KW-2449 Olverembatinib dimesylate ZM 306416 Multi-kinase inhibitor 1 c-ABL-IN-5

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Adaphostin 241127-58-2 Angiogenesis Cytoskeletal Signaling Tyrosine Kinase/Adaptors Bcr-Abl NSC-680410 Apoptosis tyrosine kinase NSC680410 inhibit chronic myelogenous leukemia 1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate NSC 680410 myeloid Inhibitor ROS p210Bcr/abl CML inhibitor

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