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Adenosine 5'-diphosphoribose sodium

Catalog No. T10247 CAS 68414-18-6

Synonyms: Adenosine 5'-diphosphoribose sodium, ADP ribose sodium

Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) is a metabolite of nicotinamide adenine nucleotide (NAD+), which is widely present in organisms.Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) is a potent intracellular Ca2+-permeable cation TRPM2 channel activator. Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) is a potent intracellular Ca2+ permeable cation TRPM2 channel activator that also induces autophagy.)

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Adenosine 5'-diphosphoribose sodium Chemical Structure

Adenosine 5'-diphosphoribose sodium, CAS 68414-18-6

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10 mg	In stock	$ 97.00
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Purity: 99.38%

Biological Description

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Description

In vitro

In mouse embryonic fibroblasts (MEFs), H2O2 treatment demonstrates that the activation of PARP-1 produced Adenosine 5'-diphosphoribose (ADP ribose), which is an activating signal for TRPM2 channels, thereby promoting Ca2+ elevation through extracellular Ca2+ influx and (or) lysosomal Ca2+ release. This process eventually activates early or late autophagy in response to different degrees of oxidative stress.[1]

Synonyms	Adenosine 5'-diphosphoribose sodium, ADP ribose sodium
Molecular Weight	581.3
Formula	C15H22N5NaO14P2
CAS No.	68414-18-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL (34.41 mM), Sonication is recommended.

H2O: 100 mg/mL (172.03 mM), Sonication is recommended.

References and Literature

1. Zhang DX, et al. The potential regulatory roles of NAD(+) and its metabolism in autophagy. Metabolism. 2016 Apr;65(4):454-62. 2. Tóth B, et al. Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13440-5.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Bioactive Compound Library Autophagy Compound Library Bioactive Compounds Library Max

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Keywords

Adenosine 5'-diphosphoribose sodium 68414-18-6 Autophagy Membrane transporter/Ion channel Metabolism TRP/TRPV Channel Endogenous Metabolite ADP ribose sodium inhibitor inhibit

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