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Adenosine amine congener

Catalog No. T7683 CAS 96760-69-9

Synonyms: ADAC

Adenosine amine congener (ADAC) (ADAC) is an agonist of selective A1 adenosine receptor,.

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Adenosine amine congener Chemical Structure

Adenosine amine congener, CAS 96760-69-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 67.00
5 mg	In stock	$ 163.00
10 mg	In stock	$ 247.00
25 mg	In stock	$ 447.00
50 mg	In stock	$ 659.00
100 mg	In stock	$ 939.00
1 mL * 10 mM (in DMSO)	In stock	$ 259.00

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Purity: 98.29%

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Description	Adenosine amine congener (ADAC) (ADAC) is an agonist of selective A1 adenosine receptor,.
In vivo	Adenosine amine congener (ADAC) was most effective in the first 24 hours after noise exposure at doses >50 μg/kg, providing up to 21 dB protection (averaged across 8-28 kHz). Pharmacokinetic studies demonstrated a short (5 min) half-life of ADAC in plasma after intravenous administration without detection of degradation products.
Animal Research	Adenosine amine congener (ADAC)??(25-300 μg/kg) was administered intraperitoneally to Wistar rats (8-10 weeks old) at intervals (6-72 hours) after exposure to traumatic noise (8-16 kHz, 110 dB sound pressure level, 2 hours). Hearing sensitivity was assessed using auditory brainstem responses (ABR) before and 12 days after noise exposure. Pharmacokinetic studies investigated ADAC concentrations in plasma after systemic (intravenous) administration[1].

Synonyms	ADAC
Molecular Weight	576.6
Formula	C28H32N8O6
CAS No.	96760-69-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 31.25 mg/mL (54.20 mM)

References and Literature

1. Vlajkovic S M , Lee K H , Wong A C Y , et al. Adenosine amine congener mitigates noise-induced cochlear injury[J]. Purinergic Signalling, 2010, 6(2):p.273-281. 2. Hao C , Telang R S , Sreevalsan S , et al. Pharmacokinetic Properties of Adenosine Amine Congener in Cochlear Perilymph after Systemic Administration[J]. BioMed Research International, 2017, 2017:1-8.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Bioactive Compound Library Anti-Viral Compound Library Immunology/Inflammation Compound Library Anti-Infection Compound Library Neuronal Signaling Compound Library Neurotransmitter Receptor Compound Library Nucleotide Compound Library Bioactive Compounds Library Max CNS-Penetrant Compound Library

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Keywords

Adenosine amine congener 96760-69-9 GPCR/G Protein Neuroscience Adenosine Receptor P1 receptor otoprotective loss hearing Inhibitor apoptotic injury systemic A1-adenosine Cochlear inhibit Ca2+ neuroprotective ADAC inhibitor

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