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Afabicin

Catalog No. T14134 CAS 1518800-35-5

Synonyms: AFN-1720, Debio 1450

Afabicin is the prodrug of Debio1452. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Afabicin, CAS 1518800-35-5

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,230.00
50 mg	6-8 weeks	$ 1,600.00
100 mg	6-8 weeks	$ 2,430.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Afabicin is the prodrug of Debio1452. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci.
In vitro	Debio1452 inhibits S. aureus, with MICs of ≤0.12 μg/mL and MIC50 and MIC90 values of 0.004 μg/mL and 0.008 μg/mL, respectively[1]. Debio1452 is highly active against staphylococci isolates, with MIC50 and MIC90 values of 0.015 μg/mL and 0.12 μg/mL, respectively.

Synonyms	AFN-1720, Debio 1450
Molecular Weight	485.43
Formula	C23H24N3O7P
CAS No.	1518800-35-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Flamm RK, et al. Activity of Debio1452, a FabI inhibitor with potent activity against Staphylococcus aureus and coagulase-negative Staphylococcus spp., including multidrug-resistant strains. Antimicrob Agents Chemother. 2015 May;59(5):2583-7.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Afabicin 1518800-35-5 Microbiology/Virology Antibacterial AFN 1720 AFN-1720 Debio 1450 AFN1720 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.