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Agnuside

Catalog No. T3868 CAS 11027-63-7

Synonyms: chasteberry oil

Agnuside (chasteberry oil) inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-glycoprotein (P-gp) ATPase activity at concentrations of 5, 25, and 100 μM, respectively.

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Agnuside, CAS 11027-63-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 39.00
5 mg	In stock	$ 98.00
10 mg	In stock	$ 148.00
25 mg	In stock	$ 249.00
50 mg	In stock	$ 369.00
100 mg	In stock	$ 548.00
1 mL * 10 mM (in DMSO)	In stock	$ 110.00

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Purity: 99.81%

Purity: 99.1%

Purity: 98.98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Agnuside (chasteberry oil) inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-glycoprotein (P-gp) ATPase activity at concentrations of 5, 25, and 100 μM, respectively.
Targets&IC50	COX-2:0.026 mg/mL
In vitro	Agnuside (0.1-10 μM) induces proliferation of MCF-7 breast cancer cells, an effect that is inhibited by the estrogen receptor antagonist fulvestrant [2].
In vivo	Agnuside (50 mg/kg) reduces acetic acid-induced writhing in mice indicating analgesia.3 It also suppresses production of the pro-inflammatory mediators' prostaglandin E2 (PGE2) and leukotriene B4 and the T cell-mediated cytokines IL-2, TNF-α, INF-γ, IL-4, IL-10, and IL-17 in splenocytes and arthritic paw tissue from arthritic adrenalectomized rats.4
Source	Natural Products > Verbenaceae > Vitex

Synonyms	chasteberry oil
Molecular Weight	466.44
Formula	C22H26O11
CAS No.	11027-63-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL

References and Literature

1. Suksamrarn A, et al. Iridoids with anti-inflammatory activity from Vitex peduncularis. Planta Med. 2002 Jan;68(1):72-3. 2. Hu Y, et al. Evaluation of the estrogenic activity of the constituents in the fruits of Vitex rotundifolia L. for the potential treatment of premenstrual syndrome. J Pharm Pharmacol. 2007 Sep;59(9):1307-12. 3. Okuyama E, et al. Pharmacologically active components of viticis fructus (Vitex rotundifolia). II. The components having analgesic effects. Chem Pharm Bull (Tokyo). 1998 Apr;46(4):655-62. 4. Pandey A, et al. Anti-arthritic activity of agnuside mediated through the down-regulation of inflammatory mediators and cytokines. Inflamm Res. 2012 Apr;61(4):293-304. 5. Najar IA, et al. Modulation of P-glycoprotein ATPase activity by some phytoconstituents. Phytother Res. 2010 Mar;24(3):454-8.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library GPCR Compound Library Terpene Natural Product Library Bioactive Compound Library Human Endogenous Metabolite Compound Library Plus Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library Immunology/Inflammation Compound Library Natural Product Library Chinese Pharmacopoeia Natural Product Library Traditional Chinese Medicine Monomer Library

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Keywords

Agnuside 11027-63-7 GPCR/G Protein Immunology/Inflammation Membrane transporter/Ion channel Neuroscience COX Prostaglandin Receptor P-gp Agnoside Inhibitor inhibit chasteberry oil inhibitor

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