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Agnuside

Catalog No. T3868   CAS 11027-63-7
Synonyms: Agnoside, Agnuside, Inhibitor, inhibit, Prostaglandin Receptor, chasteberry oil

Agnuside inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-glycoprotein (P-gp) ATPase activity at concentrations of 5, 25, and 100 μM, respectively.

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Agnuside, CAS 11027-63-7
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Purity: 98%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Agnuside inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-glycoprotein (P-gp) ATPase activity at concentrations of 5, 25, and 100 μM, respectively.
Targets&IC50 COX-2:0.026 mg/mL
In vitro Agnuside (0.1-10 μM) induces proliferation of MCF-7 breast cancer cells, an effect that is inhibited by the estrogen receptor antagonist fulvestrant [2].
In vivo Agnuside (50 mg/kg) reduces acetic acid-induced writhing in mice indicating analgesia.3 It also suppresses production of the pro-inflammatory mediators' prostaglandin E2 (PGE2) and leukotriene B4 and the T cell-mediated cytokines IL-2, TNF-α, INF-γ, IL-4, IL-10, and IL-17 in splenocytes and arthritic paw tissue from arthritic adrenalectomized rats.4
Synonyms Agnoside, Agnuside, Inhibitor, inhibit, Prostaglandin Receptor, chasteberry oil
Molecular Weight 466.439
Formula C22H26O11
CAS No. 11027-63-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Suksamrarn A, et al. Iridoids with anti-inflammatory activity from Vitex peduncularis. Planta Med. 2002 Jan;68(1):72-3. 2. Hu Y, et al. Evaluation of the estrogenic activity of the constituents in the fruits of Vitex rotundifolia L. for the potential treatment of premenstrual syndrome. J Pharm Pharmacol. 2007 Sep;59(9):1307-12. 3. Okuyama E, et al. Pharmacologically active components of viticis fructus (Vitex rotundifolia). II. The components having analgesic effects. Chem Pharm Bull (Tokyo). 1998 Apr;46(4):655-62. 4. Pandey A, et al. Anti-arthritic activity of agnuside mediated through the down-regulation of inflammatory mediators and cytokines. Inflamm Res. 2012 Apr;61(4):293-304. 5. Najar IA, et al. Modulation of P-glycoprotein ATPase activity by some phytoconstituents. Phytother Res. 2010 Mar;24(3):454-8.

Related compound libraries

This product is contained In the following compound libraries:
HIF-1 Signaling Pathway Compound Library Anti-Cardiovascular Disease Compound Library Traditional Chinese Medicine Monomer Library Natural Product Library for HTS Ion Channel Inhibitor Library Immunology/Inflammation Compound Library Anti-COVID-19 Compound Library Food as Medicine Compound Library Anti-Breast Cancer Compound Library Nonsteroidal Anti-Inflammatory Compound Library

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