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Alfuzosin hydrochloride

Catalog No. T0091 CAS 81403-68-1

Synonyms: SL 77499-10, Alfuzosin HCl

Alfuzosin hydrochloride (Alfuzosin HCl) is an α1 adrenergic receptor antagonist. It applies to treat benign prostatic hyperplasia (BPH).

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Alfuzosin hydrochloride Chemical Structure

Alfuzosin hydrochloride, CAS 81403-68-1

Pack Size	Availability	Price/USD
5 mg	In stock	$ 38.00
10 mg	In stock	$ 63.00
25 mg	In stock	$ 109.00
50 mg	In stock	$ 178.00
100 mg	In stock	$ 263.00
500 mg	In stock	$ 647.00
1 mL * 10 mM (in DMSO)	In stock	$ 41.00

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Purity: 99.61%

Biological Description

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Storage & Solubility Information

Description	Alfuzosin hydrochloride (Alfuzosin HCl) is an α1 adrenergic receptor antagonist. It applies to treat benign prostatic hyperplasia (BPH).
In vitro	Alfuzosin significantly increases whole-cell peak sodium (hNa(v)1.5) current, increases the probability of late hNa(v)1.5 single-channel openings, and significantly shortens the slow time constant for recovery from inactivation. Alfuzosin also increases hNa(v)1.5 burst duration and number of openings per burst between 2- and 3-fold. [1] Alfuzosin shows a concentration-dependent relaxing effect on rabbit corpus cavernosum (CC) pre-contracted by 10 mM phenylephrine. [2]
In vivo	Alfuzosin (300 nM) significantly prolongs action potential duration (APD)(60) in rabbit Purkinje fibers and QT in isolated rabbit hearts. [1] Alfuzosin enhances the number and amplitude of erections induced by apomorphine in spontaneous hypertensive rats (SHR). [3] Alfuzosin behaves as an alpha-adrenergic antagonist blocking the contractions induced by exogenous noradrenaline without altering spikes in both portions of the vas deferens. [4] Alfuzosin (0.03-0.3 mg kg-1, i.v.) markedly inhibits pressor responses produced by the alpha 1-selective agonist, Cirazoline but inhibits only slightly responses to the alpha 2-selective agonist, UK 14,304, in the pithed rat. Alfuzosin (1 mg kg-1, i.v.) has minimal effects against responses mediated by stimulation of prejunctional alpha 2-receptors (UK 14,304-induced inhibition of sympathetic tachycardia). Alfuzosin (0.001-1 mg kg-1, i.v.) and Prazosin (0.001-0.3 mg kg-1, i.v.) produces dose-related inhibition of the increases in urethral pressure caused by stimulation of sympathetic hypogastric nerves in the anaesthetized cat. [5]

Synonyms	SL 77499-10, Alfuzosin HCl
Molecular Weight	425.91
Formula	C19H27N5O4·HCl
CAS No.	81403-68-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10.7 mg/mL (25 mM)

H2O: 10.7 mg/mL (25 mM)

References and Literature

1. Lacerda AE, et al. J Pharmacol Exp Ther,2008, 324(2), 427-433. 2. Palea S, et al. BJU Int,2003, 91(9), 873-877. 3. Mayoux E, et al. Eur Urol,2004, 45(1), 110-116. 4. Tambaro S, et al. J Pharmacol Exp Ther,2005, 312(2), 710-717. 5. Lefèvre-Borg F, et al. Br J Pharmacol. 1993 Aug;109(4):1282-9.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Drug Repurposing Compound Library Inhibitor Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Membrane Protein-targeted Compound Library Coagulation and Anticoagulation Compound Library Approved Drug Library

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Keywords

Alfuzosin hydrochloride 81403-68-1 GPCR/G Protein Neuroscience Adrenergic Receptor bladder neck inhibit Alfuzosin urination SL 77499-10 prostatic Beta Receptor Alfuzosin Hydrochloride Alfuzosin HCl Inhibitor BPH inhibitor

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