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Alloxan monohydrate

Catalog No. T7814   CAS 2244-11-3

Alloxan Monohydrate is a glucose analog used to induce diabetes by destroying beta-cells.

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Alloxan monohydrate Chemical Structure
Alloxan monohydrate, CAS 2244-11-3
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Alloxan Monohydrate is a glucose analog used to induce diabetes by destroying beta-cells.
In vitro Alloxan caused the accumulation of ubiquitinated proteins in NRK cells through the inhibition of the proteolytic activities of the proteasome.?Alloxan directly acts on the chymotrypsin- and trypsin-like peptidase activities[1]
Molecular Weight 160.09
Formula C4H4N2O5
CAS No. 2244-11-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5mg/ml(31.23mM)

TargetMolReferences and Literature

1. Major species differences between humans and rodents in the susceptibility to pancreatic β-cell injury. 2. Zhou W , Wei L , Xiao T , et al. Diabetogenic agent alloxan is a proteasome inhibitor.[J]. Biochemical & Biophysical Research Communications, 2017, 488(2). 3. Szkuldeshi T . The mechanism of alloxan and streptozotocin action in beta cells of the rat pancreas[J]. Physiol Rev. 2001, 50.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max Ubiquitination Compound Library Human Metabolite Library Inhibitor Library Anti-Diabetic Compound Library Protease Inhibitor Library NO PAINS Compound Library Bioactive Compound Library Covalent Inhibitor Library HIF-1 Signaling Pathway Compound Library

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Keywords

Alloxan monohydrate 2244-11-3 Proteases/Proteasome Ubiquitination Proteasome B cells 20S proteasomes diabetes Inhibitor insulin diabetogenic agent Alloxan Monohydrate Alloxan inhibit 26S inhibitor

 

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