Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Alobresib (Vorolanib) is an inhibitor of BET bromodomain,is an antineoplastic drug candidate.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 67.00 | |
2 mg | In stock | $ 94.00 | |
5 mg | In stock | $ 147.00 | |
10 mg | In stock | $ 289.00 | |
25 mg | In stock | $ 563.00 | |
50 mg | In stock | $ 793.00 | |
100 mg | In stock | $ 1,090.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 162.00 |
Description | Alobresib (Vorolanib) is an inhibitor of BET bromodomain,is an antineoplastic drug candidate. |
In vitro | in vitro experiments demonstrated high sensitivity of USC cell lines to the exposure to GS-5829, GS-626510, and JQ1 with BET inhibitors causing a dose-dependent decrease in the phosphorylated levels of c-Myc and a dose-dependent increase in caspase activation (apoptosis). |
In vivo | In comparative in vivo experiments, GS-5829 and/or GS-626510 were found more effective than JQ1 at the concentrations/doses used in decreasing tumor growth in both USC-ARK1 and USC-ARK2 mouse xenograft models |
Synonyms | Vorolanib, GS-5829 |
Molecular Weight | 437.49 |
Formula | C26H23N5O2 |
CAS No. | 1637771-14-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (62.86 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Alobresib 1637771-14-2 Chromatin/Epigenetic Epigenetic Reader Domain GS 5829 Inhibitor GS5829 Vorolanib inhibit GS-5829 inhibitor