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Alogliptin Benzoate

Catalog No. T2401 CAS 850649-62-6

Synonyms: SYR 322, Alogliptin(SYR-322)benzoate

Alogliptin Benzoate (SYR 322)(SYR 322), an effective and specific DPP-4 inhibitor (IC50<10 nM), exhibits greater than 10, 000-fold selectivity over DPP-8/9. Alogliptin may inhibit inflammatory responses by preventing the toll-like receptor 4 (TLR-4)-mediated formation of proinflammatory cytokines.

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Alogliptin Benzoate, CAS 850649-62-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 43.00
10 mg	In stock	$ 56.00
25 mg	In stock	$ 75.00
50 mg	In stock	$ 72.00
100 mg	In stock	$ 129.00
200 mg	In stock	$ 193.00
500 mg	In stock	$ 323.00
1 mL * 10 mM (in DMSO)	In stock	$ 48.00

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Purity: 100%

Purity: 99.95%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Alogliptin Benzoate (SYR 322)(SYR 322), an effective and specific DPP-4 inhibitor (IC50<10 nM), exhibits greater than 10, 000-fold selectivity over DPP-8/9. Alogliptin may inhibit inflammatory responses by preventing the toll-like receptor 4 (TLR-4)-mediated formation of proinflammatory cytokines.
Targets&IC50	DPP4:<10 nM
In vitro	Alogliptin(SYR-322) is a potent inhibitor of DPP-4 and exhibits greater than 10,000 fold selectivity over the closely related serine proteases DPP-8 and DPP-9. Alogliptin is not an inhibitor of CYP-450 enzymes and does not block the hERG channel at concentrations up to 30 μM. [1]
In vivo	Alogliptin(SYR-322) produces dose-dependent improvements in glucose tolerance and increases plasma insulin levels in female Wistar fatty rats. [1] Acute administration of alogliptin results in a significant decrease in plasma DPP-4 activity, and increases plasma active GLP-1. Alogliptin improves glucose tolerance at a dose of 0.3 mg/kg and higher, with a dose-dependent increase in plasma IRI, suggesting that improved glucose tolerance results from the ability of alogliptin to enhance insulin secretion. [2]

Synonyms	SYR 322, Alogliptin(SYR-322)benzoate
Molecular Weight	461.51
Formula	C25H27N5O4
CAS No.	850649-62-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 63 mg/mL (136.5 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: 2 mg/mL (4.33 mM)

References and Literature

1. Feng J, et al. J Med Chem, 2007, 50(10), 2297-2300. 2. Asakawa T, et al. Life Sci, 2009, 85(3-4), 122-126.

Related compound libraries

This product is contained In the following compound libraries：

EMA Approved Drug Library Drug Repurposing Compound Library Highly Selective Inhibitor Library Inhibitor Library HIF-1 Signaling Pathway Compound Library Immunology/Inflammation Compound Library Ubiquitination Compound Library FDA-Approved & Pharmacopeia Drug Library Pediatric Drug Library Protease Inhibitor Library

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Keywords

Alogliptin Benzoate 850649-62-6 Apoptosis Proteases/Proteasome Ubiquitination DPP-4 Proteasome Ferroptosis inhibit SYR-322 DPP Alogliptin diabetes Dipeptidyl Peptidase Inhibitor SYR 322 Alogliptin(SYR-322)benzoate SYR322 inhibitor

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