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Amikacin disulfate

Catalog No. T6382   CAS 39831-55-5
Synonyms: Pierami, BAY-416651 sulfate, BB-K8, Amikacin sulfate

Amikacin disulfate (BAY-416651 sulfate) is a semi-synthetic aminoglycoside antibiotic derived from kanamycin A.

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Amikacin disulfate Chemical Structure
Amikacin disulfate, CAS 39831-55-5
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500 mg In stock $ 42.00
1 g In stock $ 64.00
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Purity: 99.88%
Purity: 98.67%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Amikacin disulfate (BAY-416651 sulfate) is a semi-synthetic aminoglycoside antibiotic derived from kanamycin A.
In vitro Amikacin sulfate has high affinities for 16S rRNA of the bacterial 30S ribosome, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. [1] Amikacin is active in vitro against Pseudomonas species, [2] Escherichia coli[3], Proteus species (indole-positive and indole-negative), Providencia species, Klebsiella-Enterobacter-Serratia species, Acinetobacter (formerly Mima-Herellea) species, and Citrobacter freundii.[4] [5] In vitro studies have shown that amikacin sulfate combined with a beta-lactam antibiotic acts synergistically against many clinically significant Gram-negative organisms. In vitro studies have shown that amikacin sulfate combined with beta-lactam antimicrobial agents including moxalactam or piperacillin acts synergistically against many clinically significant Gram-negative organisms. [6]
In vivo Amikacin (80 mg/kg i.v.) significantly reduced pseudomonal densities within aortic vegetations compared to controls in the experimental rabbit endocarditis model. In addition, amikacin given once daily is still more effective than the twice-daily regimen. [7] Amikacin given alone at a dose of 50 mg/kg, in one, two, or three divided doses, showed remarkable activity in model of Mycobacterium avium complex infections in beige mice. Addition of clofazimine increased the activity significantly. [8]
Synonyms Pierami, BAY-416651 sulfate, BB-K8, Amikacin sulfate
Molecular Weight 781.76
Formula C22H43N5O13·2H2O4S
CAS No. 39831-55-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 10 mM

DMSO: Insoluble

TargetMolReferences and Literature

1. Umezawa H. Jpn J Antibiot, 1979, 32 Suppl, S1-S14. 2. Kluge RM, et al. Antimicrob Agents Chemother, 1974, 6(4), 442-446. 3. Price KE, et al. Antimicrob Agents Chemother, 1974, 5(2), 143-152. 4. Sharp PM, et al. Antimicrob Agents Chemother, 1974, 5(5), 435-438. 5. Falagas ME, et al. Expert Rev Anti Infect Ther, 2012, 10(2), 207-218.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Anti-Bacterial Compound Library Bioactive Compounds Library Max Immunology/Inflammation Compound Library NO PAINS Compound Library FDA-Approved Drug Library FDA-Approved & Pharmacopeia Drug Library Antibiotics Library Clinical Compound Library Drug Repurposing Compound Library

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Keywords

Amikacin disulfate 39831-55-5 Microbiology/Virology Antibacterial Antibiotic Bacterial Amikacin Sulfate bacillary aminoglycosides Gram-negative ototoxic Inhibitor BAY 41-6551 disulfate BAY-416651 Sulfate Amikacin Disulfate ribosomal Pierami synthesis Amikacin kanamycin BAY-416651 sulfate BB-K8 BAY 416651 Sulfate infections protein Antimicrobial inhibit Amikacin sulfate BAY416651 Sulfate inhibitor

 

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