Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Amikacin disulfate (BAY-416651 sulfate) is a semi-synthetic aminoglycoside antibiotic derived from kanamycin A.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
500 mg | In stock | $ 42.00 | |
1 g | In stock | $ 64.00 |
Description | Amikacin disulfate (BAY-416651 sulfate) is a semi-synthetic aminoglycoside antibiotic derived from kanamycin A. |
In vitro | Amikacin sulfate has high affinities for 16S rRNA of the bacterial 30S ribosome, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. [1] Amikacin is active in vitro against Pseudomonas species, [2] Escherichia coli[3], Proteus species (indole-positive and indole-negative), Providencia species, Klebsiella-Enterobacter-Serratia species, Acinetobacter (formerly Mima-Herellea) species, and Citrobacter freundii.[4] [5] In vitro studies have shown that amikacin sulfate combined with a beta-lactam antibiotic acts synergistically against many clinically significant Gram-negative organisms. In vitro studies have shown that amikacin sulfate combined with beta-lactam antimicrobial agents including moxalactam or piperacillin acts synergistically against many clinically significant Gram-negative organisms. [6] |
In vivo | Amikacin (80 mg/kg i.v.) significantly reduced pseudomonal densities within aortic vegetations compared to controls in the experimental rabbit endocarditis model. In addition, amikacin given once daily is still more effective than the twice-daily regimen. [7] Amikacin given alone at a dose of 50 mg/kg, in one, two, or three divided doses, showed remarkable activity in model of Mycobacterium avium complex infections in beige mice. Addition of clofazimine increased the activity significantly. [8] |
Synonyms | Pierami, BAY-416651 sulfate, BB-K8, Amikacin sulfate |
Molecular Weight | 781.76 |
Formula | C22H43N5O13·2H2O4S |
CAS No. | 39831-55-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 10 mM
DMSO: Insoluble
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Amikacin disulfate 39831-55-5 Microbiology/Virology Antibacterial Antibiotic Bacterial Amikacin Sulfate bacillary aminoglycosides Gram-negative ototoxic Inhibitor BAY 41-6551 disulfate BAY-416651 Sulfate Amikacin Disulfate ribosomal Pierami synthesis Amikacin kanamycin BAY-416651 sulfate BB-K8 BAY 416651 Sulfate infections protein Antimicrobial inhibit Amikacin sulfate BAY416651 Sulfate inhibitor