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Aminohexylgeldanamycin

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Catalog No. T37377Cas No. 485395-71-9

Aminohexylgeldanamycin (AHGDM), a derivative of Geldanamycin, is a highly effective inhibitor of HSP90. It exhibits considerable antiangiogenic and antitumor properties[1].

Aminohexylgeldanamycin

Aminohexylgeldanamycin

😃Good
Catalog No. T37377Cas No. 485395-71-9
Aminohexylgeldanamycin (AHGDM), a derivative of Geldanamycin, is a highly effective inhibitor of HSP90. It exhibits considerable antiangiogenic and antitumor properties[1].
Pack SizePriceAvailabilityQuantity
25 mg$9206-8 weeks
50 mg$1,1806-8 weeks
100 mg$1,7906-8 weeks
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Product Introduction

Bioactivity
Description
Aminohexylgeldanamycin (AHGDM), a derivative of Geldanamycin, is a highly effective inhibitor of HSP90. It exhibits considerable antiangiogenic and antitumor properties[1].
In vitro
HPMA copolymer-aminohexylgeldanamycin conjugates are designed to target the GRP78 protein, which is expressed on the surface of prostate cancer cells[2].
Chemical Properties
Molecular Weight644.8
FormulaC34H52N4O8
Cas No.485395-71-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 200 mg/mL (310.17 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.5509 mL7.7543 mL15.5087 mL77.5434 mL
5 mM0.3102 mL1.5509 mL3.1017 mL15.5087 mL
10 mM0.1551 mL0.7754 mL1.5509 mL7.7543 mL
20 mM0.0775 mL0.3877 mL0.7754 mL3.8772 mL
50 mM0.0310 mL0.1551 mL0.3102 mL1.5509 mL
100 mM0.0155 mL0.0775 mL0.1551 mL0.7754 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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