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Amlodipine

Catalog No. T1385   CAS 88150-42-9
Synonyms: UK-48340

Amlodipine (UK-48340) is a synthetic dihydropyridine and a calcium channel blocker with antihypertensive and antianginal properties.

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Amlodipine Chemical Structure
Amlodipine, CAS 88150-42-9
Pack Size Availability Price/USD Quantity
500 mg In stock $ 45.00
1 g In stock $ 72.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.85%
Purity: 99.83%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Amlodipine (UK-48340) is a synthetic dihydropyridine and a calcium channel blocker with antihypertensive and antianginal properties.
Synonyms UK-48340
Molecular Weight 408.88
Formula C20H25ClN2O5
CAS No. 88150-42-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 76 mg/mL (138.6 mM)

Ethanol: 76 mg/mL (138.6 mM)

TargetMolReferences and Literature

1. Zhang X, et al. Circulation, 1998, 97(6), 576-580. 2. Mason RP, et al. J Mol Cell Cardiol, 1999, 31(1), 275-281. 3. Nussberger J, et al. Hypertension, 2008, 51(5), 1306-1311. 4. Mason RP, et al. J Neurochem, 1999, 72(4), 1448-1456. 5. Sharifi AM, et al. J Hypertens, 1998, 16(4), 457-466. 6. Pan X, Li R, Guo H, et al. Dihydropyridine Calcium Channel Blockers Suppress the Transcription of PD-L1 by Inhibiting the Activation of STAT1[J]. Frontiers in Pharmacology. 2021, 11: 2233.

TargetMolCitations

1. Cheng S, Jin P, Li H, et al. Evaluation of CML TKI Induced Cardiovascular Toxicity and Development of Potential Rescue Strategies in a Zebrafish Model. Frontiers in Pharmacology. 2021: 2866. 2. Pan X, Li R, Guo H, et al. Dihydropyridine Calcium Channel Blockers Suppress the Transcription of PD-L1 by Inhibiting the Activation of STAT1. Frontiers in Pharmacology. 2021 Jan 13;11:539261. doi: 10.3389/fphar.2020.539261. eCollection 2020.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Cardiovascular Disease Compound Library Inhibitor Library Orally Active Compound Library Approved Drug Library Drug-induced Liver Injury (DILI) Compound Library FDA-Approved Drug Library

Related Products

Related compounds with same targets
Ranolazine dihydrochloride Myomodulin Fantofarone Ca2+ channel agonist 1 Atherosperminine NNC 55-0396 Levosemotiadil Dehydronitrosonisoldipine

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Keywords

Amlodipine 88150-42-9 Membrane transporter/Ion channel Metabolism Calcium Channel dihydropyridine hypertension Ca2+ channels inhibit UK48340 oral UK 48340 antianginal Inhibitor Ca channels UK-48340 inhibitor

 

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