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Amuvatinib

Catalog No. T2516   CAS 850879-09-3
Synonyms: c-Kit, c-Met/HGFR, Apoptosis, Amuvatinib, Fms like tyrosine kinase 3, Cluster of differentiation antigen 135, HPK-56, RET, MP-470, FLT3, CD117, CD135, Platelet-derived growth factor receptor, PDGFR, SCFR, MP 470, Inhibitor, RAD51, HPK 56, HPK56, MP470, inhibit

Amuvatinib is an orally bioavailable synthetic carbothioamide with potential antineoplastic activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Amuvatinib, CAS 850879-09-3
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Purity: 98%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Amuvatinib is an orally bioavailable synthetic carbothioamide with potential antineoplastic activity.
Targets&IC50 FLT3 (D835Y):81 nM, PDGFRα (V561D):40 nM, c-Kit (D816H):10 nM
Kinase Assay Kinase inhibition assay of c-Kit and PDGFRα: For the testing of inhibitory activity against c-Kit and PDGFRα, enzymes are incubated with varying concentrations of MP-470 and radiolabeled γ-32P-ATP. After 30 min, the reaction mixtures are electrophoresed on an acrylamide gel and autophosphorylation, quantitated by the amount of radioactivity incorporated into the enzyme, is assayed.
Cell Research Cells are plated at a density of 2 × 103 to 1 × 104 cells per well in 100 μL medium on day 0 in 96-well Falcon microtitier plates. On day 1, ten μL of serial dilutions of MP-470 are added to the plates in quadruplicates. After incubation for 4 days, the cells are fixed with 10% Trichloroacetic acid solution. Subsequently, they are labeled with 0.04% Sulforhodamine B (SRB) in 1% acetic acid. After multiple washes to remove the excess dye, 100 μL of 50 mM Tris solution is added to each well in order to dissolve the dye. The absorbance of each well is read on a plate reader at 570 nm. Date are expressed as the percentage of survival of control calculated from the absorbance corrected for background absorbance. The surviving percent of cells is determined by dividing the mean absorbance values of the monoclonal antibody by mean absorbance values of the control and multiplying by 100.(Only for Reference)
Synonyms c-Kit, c-Met/HGFR, Apoptosis, Amuvatinib, Fms like tyrosine kinase 3, Cluster of differentiation antigen 135, HPK-56, RET, MP-470, FLT3, CD117, CD135, Platelet-derived growth factor receptor, PDGFR, SCFR, MP 470, Inhibitor, RAD51, HPK 56, HPK56, MP470, inhibit
Molecular Weight 447.51
Formula C23H21N5O3S
CAS No. 850879-09-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 30 mg/mL (67 mM)

Ethanol: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Han H W, Hahn S, Jeong H Y, et al. LINCS L1000 dataset-based repositioning of CGP-60474 as a highly potent anti-endotoxemic agent. Scientific Reports. 2018 Oct 8;8(1):14969 2. Hurley LH, et al. World Patent, WO/2005/037825. 3. Mahadevan D, et al. Oncogene, 2007, 26(27), 3909-3919. 4. Qi W, et al. BMC Cancer, 2009, 9, 142. 5. Welsh JW, et al. Radiat Oncol, 2009, 4, 69. 6. Han H W, Hahn S, Jeong H Y, et al. LINCS L1000 dataset-based repositioning of CGP-60474 as a highly potent anti-endotoxemic agent[J]. Scientific reports. 2018 Oct 8;8(1):14969.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Compound Library Anti-Lung Cancer Compound Library Cytokine Inhibitor Library Anti-Pancreatic Cancer Compound Library Inhibitor Library DNA Damage & Repair Compound Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Kinase Inhibitor Library Apoptosis Compound Library

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