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Apigenin-7-glucuronide

Catalog No. T5S1026 CAS 29741-09-1

Synonyms: Apigenin 7-O-glucuronide

Apigenin-7-glucuronide (Apigenin 7-O-glucuronide) possesses multiple activities, including antioxidant, anti-inflammatory, and aldose reductase inhibitory activities, it can inhibit MMP activities (IC50s: 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Apigenin-7-glucuronide Chemical Structure

Apigenin-7-glucuronide, CAS 29741-09-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 62.00
5 mg	In stock	$ 133.00
10 mg	In stock	$ 226.00
25 mg	In stock	$ 397.00
50 mg	In stock	$ 597.00
100 mg	In stock	$ 848.00
1 mL * 10 mM (in DMSO)	In stock	$ 147.00

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Purity: 99.27%

Purity: 97.42%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Apigenin-7-glucuronide (Apigenin 7-O-glucuronide) possesses multiple activities, including antioxidant, anti-inflammatory, and aldose reductase inhibitory activities, it can inhibit MMP activities (IC50s: 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively).
Targets&IC50	MMP13:0.27 μM, MMP9:17.52 μM, MMP8:22.39 μM, MMP3:12.87 μM
In vivo	Apigenin-7-O-β-D-glucuronide (AG) suppressed the release of nitric oxide (NO), prostaglandin E2 (PGE2), and tumour necrosis factor-α (TNF-α) in LPS-stimulated RAW 264.7 macrophages in a dose-dependent manner without affecting cell viability. Additionally, AG suppressed LPS-induced mRNA expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and TNF-α. AG treatment decreased the translocation of c-Jun into the nucleus and decreased activator protein-1 (AP-1)-mediated luciferase activity through the inhibition of both p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) phosphorylation [2].
Source	Natural Products > Lamiaceae > Phlomis

Synonyms	Apigenin 7-O-glucuronide
Molecular Weight	446.36
Formula	C21H18O11
CAS No.	29741-09-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (112.02 mM)

References and Literature

1. Crascì L, et al. Correlating In Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids. Planta Med. 2017 Jul;83(11):901-911. 2. Hu W, et al. Apigenin-7-O-β-D-glucuronide inhibits LPS-induced inflammation through the inactivation of AP-1 and MAPK signaling pathways in RAW 264.7 macrophages and protects mice against endotoxin shock. Food Funct. 2016 Feb;7(2):1002-13.

Related compound libraries

This product is contained In the following compound libraries：

Traditional Chinese Medicine Monomer Library Inhibitor Library Natural Product Library Angiogenesis related Compound Library Flavonoid Natural Product Library Antioxidant Compound Library Anti-Aging Compound Library Oxidation-Reduction Compound Library Human Metabolite Library Food as Medicine Compound Library

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Related compounds with same targets

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Keywords

Apigenin-7-glucuronide 29741-09-1 Proteases/Proteasome MMP inhibit Apigenin 7-O-glucuronide Matrix metalloproteinases Inhibitor Apigenin7glucuronide Apigenin 7 glucuronide inhibitor

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