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Arazine

Catalog No. T10363 CAS 135304-07-3

Synonyms: N-Acetyl-S-farnesyl-L-cysteine

Arazine (N-Acetyl-S-farnesyl-L-cysteine) can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site. Arazine is a cell-permeable modulator of G protein and GPCR signaling.

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Arazine, CAS 135304-07-3

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Biological Description

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Description	Arazine (N-Acetyl-S-farnesyl-L-cysteine) can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site. Arazine is a cell-permeable modulator of G protein and GPCR signaling.
In vitro	Arazine (10–100 μM; 8h) significantly affects the HMEC-1 cell viability as measured by trypan blue exclusion in HMEC-1 cell. Arazine (2h) inhibits ATPγS induced CXCL1, CXCL8 and CCL2 production as a dose-dependent manner in HMEC-1 cell[2].
In vivo	Arazine (2,000 μg/20 μl) produces a dose-dependent inhibition of the TPA-induced edema, with the maximal reduction of edema approaching 73%, with an ED50 of 55 μg/20 μl[2].

Synonyms	N-Acetyl-S-farnesyl-L-cysteine
Molecular Weight	367.55
Formula	C20H33NO3S
CAS No.	135304-07-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Adhami K, et al. N-acetyl-S-farnesyl-l-cysteine suppresses chemokine production by human dermal microvascular endothelial cells.Exp Dermatol. 2012 Sep;21(9):700-5. 2. Gordon JS, et al. Topical N-acetyl-S-farnesyl-L-cysteine inhibits mouse skin inflammation, and unlike dexamethasone, its effects are restricted to the application site.J Invest Dermatol. 2008 Mar;128(3):643-54. Epub 2007 Sep 20.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Arazine 135304-07-3 Others inhibit cell-permeable substrate N-Acetyl-S-farnesyl-L-cysteine Inhibitor modulator inhibitor

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