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Arctiin

Catalog No. T2766 CAS 20362-31-6

Synonyms: Arctigenin-4-glucoside, Arctii, NSC 315527

Arctiin (Arctigenin-4-glucoside) acts on an agonists of the adiponectin receptor 1 with anti-cancer effects.

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Arctiin, CAS 20362-31-6

Pack Size	Availability	Price/USD
25 mg	In stock	$ 34.00
50 mg	In stock	$ 48.00
100 mg	In stock	$ 68.00
1 mL * 10 mM (in DMSO)	In stock	$ 53.00

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Purity: 99.81%

Purity: 98.22%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Arctiin (Arctigenin-4-glucoside) acts on an agonists of the adiponectin receptor 1 with anti-cancer effects.
In vitro	Arctiin induces growth inhibition and dephosphorylates the tumor-suppressor retinoblastoma protein in human immortalized keratinocyte HaCaT cells. The growth inhibition caused by arctiin is associated with the downregulation of cyclin D1 protein expression. The arctiin-induced suppression of cyclin D1 protein expression occurs in various types of human tumor cells, including osteosarcoma, lung, colorectal, cervical and breast cancer, melanoma, transformed renal cells and prostate cancer[1].
In vivo	Arctiin has anti-cancer properties in animal models. arctiin has a remarkable anti-tumor-promoting effect as seen in a two-stage carcinogenesis test of mouse skin tumors induced by 7,12-dimethylbenz[α]anthracene(DMBA) as an initiator and 12-Otetradecanoyl phorbol-13-acetate (TPA) as a promoter by topical and oral administration. It also has a protective effect on 2-amino-1-methyl-6- phenylimidazo[4,5-β]pyridine (PhIP)-induced carcinogenesis particularly in the mammary gland during the promotion period[1]. Arctiin is orally effective against either IFV-inoculated normal or 5-fluorouracil (5-FU)-treated mice[3].
Cell Research	HaCaT cells are plated at 1×105 cells in 25-mm-diameter dishes. Twenty-four hours after plating, various concentrations of arctiin are added to the culture medium. From the first to the third day after plating, the number of viable cells is counted by the trypan blue dye exclusion test.(Only for Reference)
Source	Natural Products > Asteraceae > Arctium

Synonyms	Arctigenin-4-glucoside, Arctii, NSC 315527
Molecular Weight	534.55
Formula	C27H34O11
CAS No.	20362-31-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 37 mg/mL (69.2 mM)

Ethanol: 93 mg/mL (174 mM)

DMSO: 93 mg/mL (174 mM)

References and Literature

1. Matsuzaki Y, et al. Oncol Rep. 2008, 19(3):721-7. 2. Hayashi K, et al. Biol Pharm Bull. 2010, 33(7):1199-205. 3. Sun Y, et al. PLoS One. 2013, 8(5):e63354.

Citations

1. Liu Y, Hou M, Pan Z, et al. Arctiin-reinforced antioxidant microcarrier antagonizes osteoarthritis progression. Journal of Nanobiotechnology. 2022, 20(1): 1-20

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Anti-Cancer Active Compound Library Membrane Protein-targeted Compound Library Food as Medicine Compound Library Natural Product Library for HTS NO PAINS Compound Library Bioactive Compounds Library Max Anti-COVID-19 Compound Library Anti-Metabolism Disease Compound Library Anti-Obesity Compound Library

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Keywords

Arctiin 20362-31-6 GPCR/G Protein Adiponectin receptor Inhibitor NSC315527 Arctigenin-4-glucoside NSC-315527 Arctii inhibit NSC 315527 inhibitor

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